Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis
Abstract Increasing evidence shows that abnormal copper (Cu) metabolism is highly related to many diseases, such as Alzheimer's disease, Wilson's disease, hematological malignancies and Menkes disease. Very recently, cuproptosis, a Cu‐dependent, programmed cell death was firstly described...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-09-01
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| Series: | ChemistryOpen |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/open.202300078 |
| _version_ | 1797674039567712256 |
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| author | Ting‐En Peng Feng Qiu Yunwei Qu Prof. Changmin Yu Prof. Xiamin Cheng Prof. Lin Li |
| author_facet | Ting‐En Peng Feng Qiu Yunwei Qu Prof. Changmin Yu Prof. Xiamin Cheng Prof. Lin Li |
| author_sort | Ting‐En Peng |
| collection | DOAJ |
| description | Abstract Increasing evidence shows that abnormal copper (Cu) metabolism is highly related to many diseases, such as Alzheimer's disease, Wilson's disease, hematological malignancies and Menkes disease. Very recently, cuproptosis, a Cu‐dependent, programmed cell death was firstly described by Tsvetkov et al. in 2022. Their findings may provide a new perspective for the treatment of related diseases. However, the concrete mechanisms of these diseases, especially cuproptosis, remain completely unclear, the reason of which may be a lack of reliable tools to conduct highly selective, sensitive and high‐resolution imaging of Cu in complex life systems. So far, numerous small‐molecular fluorescent probes have been designed and utilized to explore the Cu signal pathway. Among them, fluorescence turn‐on probes greatly enhance the resolution and accuracy of imaging and may be a promising tool for research of investigation into cuproptosis. This review summarizes the probes developed in the past decade which have the potential to study cuproptosis, focusing on the design strategies, luminescence mechanism and biological‐imaging applications. Besides, we put forward some ideas concerning the design of next‐generation probes for cuproptosis, aiming to tackle the main problems in this new field. Furthermore, the prospect of cuproptosis in the treatment of corresponding diseases is also highlighted. |
| first_indexed | 2024-03-11T21:54:21Z |
| format | Article |
| id | doaj.art-07b92d98742a4d8599957748ec03cc8f |
| institution | Directory Open Access Journal |
| issn | 2191-1363 |
| language | English |
| last_indexed | 2024-03-11T21:54:21Z |
| publishDate | 2023-09-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | ChemistryOpen |
| spelling | doaj.art-07b92d98742a4d8599957748ec03cc8f2023-09-26T05:26:39ZengWiley-VCHChemistryOpen2191-13632023-09-01129n/an/a10.1002/open.202300078Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for CuproptosisTing‐En Peng0Feng Qiu1Yunwei Qu2Prof. Changmin Yu3Prof. Xiamin Cheng4Prof. Lin Li5Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 ChinaThe Institute of Flexible Electronics (IFE, Future Technologies) Xiamen University Xiamen 361005 ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 ChinaAbstract Increasing evidence shows that abnormal copper (Cu) metabolism is highly related to many diseases, such as Alzheimer's disease, Wilson's disease, hematological malignancies and Menkes disease. Very recently, cuproptosis, a Cu‐dependent, programmed cell death was firstly described by Tsvetkov et al. in 2022. Their findings may provide a new perspective for the treatment of related diseases. However, the concrete mechanisms of these diseases, especially cuproptosis, remain completely unclear, the reason of which may be a lack of reliable tools to conduct highly selective, sensitive and high‐resolution imaging of Cu in complex life systems. So far, numerous small‐molecular fluorescent probes have been designed and utilized to explore the Cu signal pathway. Among them, fluorescence turn‐on probes greatly enhance the resolution and accuracy of imaging and may be a promising tool for research of investigation into cuproptosis. This review summarizes the probes developed in the past decade which have the potential to study cuproptosis, focusing on the design strategies, luminescence mechanism and biological‐imaging applications. Besides, we put forward some ideas concerning the design of next‐generation probes for cuproptosis, aiming to tackle the main problems in this new field. Furthermore, the prospect of cuproptosis in the treatment of corresponding diseases is also highlighted.https://doi.org/10.1002/open.202300078bioimagingcoppercuproptosisfluorescent probefluorescence turn on |
| spellingShingle | Ting‐En Peng Feng Qiu Yunwei Qu Prof. Changmin Yu Prof. Xiamin Cheng Prof. Lin Li Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis ChemistryOpen bioimaging copper cuproptosis fluorescent probe fluorescence turn on |
| title | Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis |
| title_full | Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis |
| title_fullStr | Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis |
| title_full_unstemmed | Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis |
| title_short | Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis |
| title_sort | current and future of turn on based small molecule copper probes for cuproptosis |
| topic | bioimaging copper cuproptosis fluorescent probe fluorescence turn on |
| url | https://doi.org/10.1002/open.202300078 |
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