Prasugrel, a Platelet P2Y12 Receptor Antagonist, Improves Abnormal Gait in a Novel Murine Model of Thrombotic Hindlimb Ischemia

Prasugrel, a Platelet P2Y12 Receptor Antagonist, Improves Abnormal Gait in a Novel Murine Model of Thrombotic Hindlimb Ischemia

BackgroundThe efficacy of P2Y12 inhibition for the prevention of cardiovascular events in patients with peripheral arterial disease (PAD) has been established. However, the therapeutic effects on ischemic limb complications are less clear. Accordingly, we aimed to develop a novel murine model of thr...

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Bibliographic Details
Main Authors: Kousaku Ohno, Atsuyuki Tomizawa, Makoto Mizuno, Joseph A. Jakubowski, Atsuhiro Sugidachi
Format: Article
Language:English
Published: Wiley 2016-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
femoral artery thrombosis
gait abnormalities
limb ischemia
P2Y12
prasugrel
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002889

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