Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers
Globally, cancer is one of the deadliest diseases, needing a meticulous diagnosis and targeted treatment plan to achieve an initial prognosis, followed by precision and optimization in treatment. Nonselective targeting, difficulty in accurately monitoring treatment end-results, serious drug side-eff...
| Główni autorzy: | , , , , , , , , , |
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| Format: | Artykuł |
| Język: | English |
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MDPI AG
2023-08-01
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| Seria: | Journal of Nanotheranostics |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.mdpi.com/2624-845X/4/3/16 |
| _version_ | 1827725671080656896 |
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| author | Paul A. Akpa Ikechukwu E. Peter Akachukwu M. Onwuka Bonaventure C. Obi Maureen O. Akunne Chukwuemeka S. Nworu Paul M. Ejikeme Theophine C. Akunne Anthony A. Attama Peter A. Akah |
| author_facet | Paul A. Akpa Ikechukwu E. Peter Akachukwu M. Onwuka Bonaventure C. Obi Maureen O. Akunne Chukwuemeka S. Nworu Paul M. Ejikeme Theophine C. Akunne Anthony A. Attama Peter A. Akah |
| author_sort | Paul A. Akpa |
| collection | DOAJ |
| description | Globally, cancer is one of the deadliest diseases, needing a meticulous diagnosis and targeted treatment plan to achieve an initial prognosis, followed by precision and optimization in treatment. Nonselective targeting, difficulty in accurately monitoring treatment end-results, serious drug side-effects, and severity of disease resulting in metastasis are the key flaws of traditional techniques. Nanotechnology and nanoparticles possess special features to completely transform the field of diagnosis and treatment of cancer. A holistic strategy that employs a dual function of diagnosis and therapy while utilizing a nanocarrier is referred to as a nanotheranostic. The nanotheranostic framework was created to surmount a variety of biological and physiological obstacles, effectively delivering the cargo to the intended target location, while simultaneously facilitating therapeutic intervention, surveillance, and validation to demonstrate improved treatment effectiveness. As a result, a nanotheranostic platform can be useful for targeted drug delivery, release, and distribution assessment, in addition to patient classification and survival. Nanotheranostic techniques also lead to reduced drug side-effects compared with conventional therapies. In this review, we outline current studies on nanotheranostics and their advantages over conventional treatment strategies, the applications and challenges/limitations of nanotheranostics, and the mechanisms of targeting in breast and prostate cancers. |
| first_indexed | 2024-03-10T22:34:48Z |
| format | Article |
| id | doaj.art-07bc720bb1424b10a16d94e274ca24c3 |
| institution | Directory Open Access Journal |
| issn | 2624-845X |
| language | English |
| last_indexed | 2024-03-10T22:34:48Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Nanotheranostics |
| spelling | doaj.art-07bc720bb1424b10a16d94e274ca24c32023-11-19T11:28:19ZengMDPI AGJournal of Nanotheranostics2624-845X2023-08-014334638310.3390/jnt4030016Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate CancersPaul A. Akpa0Ikechukwu E. Peter1Akachukwu M. Onwuka2Bonaventure C. Obi3Maureen O. Akunne4Chukwuemeka S. Nworu5Paul M. Ejikeme6Theophine C. Akunne7Anthony A. Attama8Peter A. Akah9Drug Delivery and Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410105, NigeriaNanotheranostics Drug Discovery Research Group, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410105, NigeriaNanotheranostics Drug Discovery Research Group, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410105, NigeriaNanotheranostics Drug Discovery Research Group, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410105, NigeriaNanotheranostics Drug Discovery Research Group, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410105, NigeriaDepartment of Pharmacology and Toxicology, University of Nigeria, Nsukka 410105, NigeriaNanotheranostics Drug Discovery Research Group, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410105, NigeriaNanotheranostics Drug Discovery Research Group, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410105, NigeriaDrug Delivery and Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410105, NigeriaNanotheranostics Drug Discovery Research Group, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410105, NigeriaGlobally, cancer is one of the deadliest diseases, needing a meticulous diagnosis and targeted treatment plan to achieve an initial prognosis, followed by precision and optimization in treatment. Nonselective targeting, difficulty in accurately monitoring treatment end-results, serious drug side-effects, and severity of disease resulting in metastasis are the key flaws of traditional techniques. Nanotechnology and nanoparticles possess special features to completely transform the field of diagnosis and treatment of cancer. A holistic strategy that employs a dual function of diagnosis and therapy while utilizing a nanocarrier is referred to as a nanotheranostic. The nanotheranostic framework was created to surmount a variety of biological and physiological obstacles, effectively delivering the cargo to the intended target location, while simultaneously facilitating therapeutic intervention, surveillance, and validation to demonstrate improved treatment effectiveness. As a result, a nanotheranostic platform can be useful for targeted drug delivery, release, and distribution assessment, in addition to patient classification and survival. Nanotheranostic techniques also lead to reduced drug side-effects compared with conventional therapies. In this review, we outline current studies on nanotheranostics and their advantages over conventional treatment strategies, the applications and challenges/limitations of nanotheranostics, and the mechanisms of targeting in breast and prostate cancers.https://www.mdpi.com/2624-845X/4/3/16cancertargeted approachnanotheranosticsnanocarrierselective therapy |
| spellingShingle | Paul A. Akpa Ikechukwu E. Peter Akachukwu M. Onwuka Bonaventure C. Obi Maureen O. Akunne Chukwuemeka S. Nworu Paul M. Ejikeme Theophine C. Akunne Anthony A. Attama Peter A. Akah Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers Journal of Nanotheranostics cancer targeted approach nanotheranostics nanocarrier selective therapy |
| title | Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers |
| title_full | Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers |
| title_fullStr | Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers |
| title_full_unstemmed | Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers |
| title_short | Nanotheranostics: Platforms, Current Applications, and Mechanisms of Targeting in Breast and Prostate Cancers |
| title_sort | nanotheranostics platforms current applications and mechanisms of targeting in breast and prostate cancers |
| topic | cancer targeted approach nanotheranostics nanocarrier selective therapy |
| url | https://www.mdpi.com/2624-845X/4/3/16 |
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