Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients
ObjectiveCoronary microvascular dysfunction (CMD) may associate with adverse cardiovascular events in obese patients. Coronary angiography-derived index of microcirculatory resistance (caIMR) is proposed as a less-invasive and pressure-wire-free index to assess CMD. We aimed to investigate the impac...
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Frontiers Media S.A.
2022-08-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.922264/full |
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author | Cailin Feng Fuad A. Abdu Abdul-Quddus Mohammed Wen Zhang Lu Liu Guoqing Yin Yundi Feng Ayman A. Mohammed Redhwan M. Mareai Xian Lv Tingting Shi Yawei Xu Xuejing Yu Wenliang Che Wenliang Che |
author_facet | Cailin Feng Fuad A. Abdu Abdul-Quddus Mohammed Wen Zhang Lu Liu Guoqing Yin Yundi Feng Ayman A. Mohammed Redhwan M. Mareai Xian Lv Tingting Shi Yawei Xu Xuejing Yu Wenliang Che Wenliang Che |
author_sort | Cailin Feng |
collection | DOAJ |
description | ObjectiveCoronary microvascular dysfunction (CMD) may associate with adverse cardiovascular events in obese patients. Coronary angiography-derived index of microcirculatory resistance (caIMR) is proposed as a less-invasive and pressure-wire-free index to assess CMD. We aimed to investigate the impact of coronary microvascular function assessed by caIMR in patients with overweight and chronic coronary syndrome (CCS).MethodsCCS patients who underwent coronary angiography between 2015 to 2018 were included. Overweight was defined as BMI≥24.0kg/m². Impaired coronary microvascular function was defined as caIMR≥25U. The patients were classified according to BMI and caIMR. The primary endpoint was major adverse cardiac events (MACE). Kaplan-Meier and Cox regression analyses evaluated the association between caIMR and MACE.ResultsTwo hundred and eighty-two CCS patients were enrolled. Among these, 169 (59.93%) were overweight. Impaired coronary microvascular function was higher in overweight patients than in patients with normal weight (49.70% vs. 38.05%; P=0.035). During 35 months of follow-up, 33 MACE had occurred. Among the total CCS population, MACE was higher in patients with high caIMR than in low caIMR (18.11% vs. 6.45%, P=0.003). In subgroups analysis, MACE was higher in overweight patients with high caIMR than low caIMR (20.24% vs. 7.06%, P=0.014), while there were no significant differences in normal-weight patients. Multivariate Cox analysis demonstrated that caIMR≥25 was independently associated with MACE in overweight patients (HR, 2.87; 95% CI, 1.12-7.30; P=0.027) but not in the normal-weight patients. In addition, caIMR showed a significant predictive value for adverse outcomes in overweight patients and provided an incremental prediction when added to a prediction model with BMI.ConclusionsImpaired coronary microvascular function assessed by caIMR was common and is an independent predictor of MACE in overweight patients with CCS. |
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spelling | doaj.art-07c067164c3640adacb82caf02454cd22022-12-22T02:33:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.922264922264Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patientsCailin Feng0Fuad A. Abdu1Abdul-Quddus Mohammed2Wen Zhang3Lu Liu4Guoqing Yin5Yundi Feng6Ayman A. Mohammed7Redhwan M. Mareai8Xian Lv9Tingting Shi10Yawei Xu11Xuejing Yu12Wenliang Che13Wenliang Che14Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaRainMed Medical, Suzhou, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital Chongming Branch, Shanghai, ChinaObjectiveCoronary microvascular dysfunction (CMD) may associate with adverse cardiovascular events in obese patients. Coronary angiography-derived index of microcirculatory resistance (caIMR) is proposed as a less-invasive and pressure-wire-free index to assess CMD. We aimed to investigate the impact of coronary microvascular function assessed by caIMR in patients with overweight and chronic coronary syndrome (CCS).MethodsCCS patients who underwent coronary angiography between 2015 to 2018 were included. Overweight was defined as BMI≥24.0kg/m². Impaired coronary microvascular function was defined as caIMR≥25U. The patients were classified according to BMI and caIMR. The primary endpoint was major adverse cardiac events (MACE). Kaplan-Meier and Cox regression analyses evaluated the association between caIMR and MACE.ResultsTwo hundred and eighty-two CCS patients were enrolled. Among these, 169 (59.93%) were overweight. Impaired coronary microvascular function was higher in overweight patients than in patients with normal weight (49.70% vs. 38.05%; P=0.035). During 35 months of follow-up, 33 MACE had occurred. Among the total CCS population, MACE was higher in patients with high caIMR than in low caIMR (18.11% vs. 6.45%, P=0.003). In subgroups analysis, MACE was higher in overweight patients with high caIMR than low caIMR (20.24% vs. 7.06%, P=0.014), while there were no significant differences in normal-weight patients. Multivariate Cox analysis demonstrated that caIMR≥25 was independently associated with MACE in overweight patients (HR, 2.87; 95% CI, 1.12-7.30; P=0.027) but not in the normal-weight patients. In addition, caIMR showed a significant predictive value for adverse outcomes in overweight patients and provided an incremental prediction when added to a prediction model with BMI.ConclusionsImpaired coronary microvascular function assessed by caIMR was common and is an independent predictor of MACE in overweight patients with CCS.https://www.frontiersin.org/articles/10.3389/fendo.2022.922264/fullcoronary microvascular dysfunctioncoronary angiography-derived index of microcirculatory resistanceoverweightchronic coronary syndromeclinical outcomes |
spellingShingle | Cailin Feng Fuad A. Abdu Abdul-Quddus Mohammed Wen Zhang Lu Liu Guoqing Yin Yundi Feng Ayman A. Mohammed Redhwan M. Mareai Xian Lv Tingting Shi Yawei Xu Xuejing Yu Wenliang Che Wenliang Che Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients Frontiers in Endocrinology coronary microvascular dysfunction coronary angiography-derived index of microcirculatory resistance overweight chronic coronary syndrome clinical outcomes |
title | Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients |
title_full | Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients |
title_fullStr | Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients |
title_full_unstemmed | Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients |
title_short | Prognostic impact of coronary microvascular dysfunction assessed by caIMR in overweight with chronic coronary syndrome patients |
title_sort | prognostic impact of coronary microvascular dysfunction assessed by caimr in overweight with chronic coronary syndrome patients |
topic | coronary microvascular dysfunction coronary angiography-derived index of microcirculatory resistance overweight chronic coronary syndrome clinical outcomes |
url | https://www.frontiersin.org/articles/10.3389/fendo.2022.922264/full |
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