Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer
PURPOSE: To investigate the effects of pre-existing sleep disorders on the survival outcomes of women receiving standard treatments for breast invasive ductal carcinoma (IDC). METHODS: We recruited patients from the Taiwan Cancer Registry Database who had received surgery for clinical stage I–III br...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/798 |
| _version_ | 1797488621804060672 |
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| author | Yen-Chang Chen Wan-Ming Chen Ming-Feng Chiang Ben-Chang Shia Szu-Yuan Wu |
| author_facet | Yen-Chang Chen Wan-Ming Chen Ming-Feng Chiang Ben-Chang Shia Szu-Yuan Wu |
| author_sort | Yen-Chang Chen |
| collection | DOAJ |
| description | PURPOSE: To investigate the effects of pre-existing sleep disorders on the survival outcomes of women receiving standard treatments for breast invasive ductal carcinoma (IDC). METHODS: We recruited patients from the Taiwan Cancer Registry Database who had received surgery for clinical stage I–III breast IDC. The Cox proportional hazards model was used to analyze all-cause mortality. We categorized the patients into those with and without sleep disorders (Groups 1 and 2, respectively) through propensity score matching. RESULTS: In the multivariate Cox regression analysis, the adjusted hazard ratio for all-cause mortality for Group 1 compared with Group 2 was 1.51 (95% confidence interval: 1.19, 1.91; <i>p</i> < 0.001). CONCLUSION: Our study demonstrated that the sleep disorder group had poorer survival rates than the non-sleep disorder group in breast cancer. Therefore, patients should be screened and evaluated for pre-existing sleep disorders prior to breast surgery, with such disorders serving as a predictor of survival in patients with breast cancer. Future studies may investigate the survival benefits of pharmacological and behavioral treatments for sleep problems in patients with breast cancer. |
| first_indexed | 2024-03-10T00:04:54Z |
| format | Article |
| id | doaj.art-07c127dfcad449c8b784aa37346b242f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:04:54Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-07c127dfcad449c8b784aa37346b242f2023-11-23T16:08:50ZengMDPI AGCancers2072-66942022-02-0114379810.3390/cancers14030798Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast CancerYen-Chang Chen0Wan-Ming Chen1Ming-Feng Chiang2Ben-Chang Shia3Szu-Yuan Wu4Division of Chest Medicine, Department of Internal Medicine, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265, TaiwanGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 242062, TaiwanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265, TaiwanGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 242062, TaiwanGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 242062, TaiwanPURPOSE: To investigate the effects of pre-existing sleep disorders on the survival outcomes of women receiving standard treatments for breast invasive ductal carcinoma (IDC). METHODS: We recruited patients from the Taiwan Cancer Registry Database who had received surgery for clinical stage I–III breast IDC. The Cox proportional hazards model was used to analyze all-cause mortality. We categorized the patients into those with and without sleep disorders (Groups 1 and 2, respectively) through propensity score matching. RESULTS: In the multivariate Cox regression analysis, the adjusted hazard ratio for all-cause mortality for Group 1 compared with Group 2 was 1.51 (95% confidence interval: 1.19, 1.91; <i>p</i> < 0.001). CONCLUSION: Our study demonstrated that the sleep disorder group had poorer survival rates than the non-sleep disorder group in breast cancer. Therefore, patients should be screened and evaluated for pre-existing sleep disorders prior to breast surgery, with such disorders serving as a predictor of survival in patients with breast cancer. Future studies may investigate the survival benefits of pharmacological and behavioral treatments for sleep problems in patients with breast cancer.https://www.mdpi.com/2072-6694/14/3/798breast cancerinvasive ductal carcinomasleep disordersurvivalrisk factor |
| spellingShingle | Yen-Chang Chen Wan-Ming Chen Ming-Feng Chiang Ben-Chang Shia Szu-Yuan Wu Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer Cancers breast cancer invasive ductal carcinoma sleep disorder survival risk factor |
| title | Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer |
| title_full | Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer |
| title_fullStr | Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer |
| title_full_unstemmed | Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer |
| title_short | Association between Pre-Existing Sleep Disorders and Survival Rates of Patients with Breast Cancer |
| title_sort | association between pre existing sleep disorders and survival rates of patients with breast cancer |
| topic | breast cancer invasive ductal carcinoma sleep disorder survival risk factor |
| url | https://www.mdpi.com/2072-6694/14/3/798 |
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