FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies
FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor,...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.880077/full |
| _version_ | 1818027467402641408 |
|---|---|
| author | Wenyue Shen Wenyue Shen Quanwei Zhou Quanwei Zhou Chenxi Peng Chenxi Peng Jiaheng Li Jiaheng Li Qizhi Yuan Qizhi Yuan Hecheng Zhu Hecheng Zhu Ming Zhao Xingjun Jiang Xingjun Jiang Weidong Liu Weidong Liu Caiping Ren Caiping Ren Caiping Ren Caiping Ren |
| author_facet | Wenyue Shen Wenyue Shen Quanwei Zhou Quanwei Zhou Chenxi Peng Chenxi Peng Jiaheng Li Jiaheng Li Qizhi Yuan Qizhi Yuan Hecheng Zhu Hecheng Zhu Ming Zhao Xingjun Jiang Xingjun Jiang Weidong Liu Weidong Liu Caiping Ren Caiping Ren Caiping Ren Caiping Ren |
| author_sort | Wenyue Shen |
| collection | DOAJ |
| description | FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases especially tumorigenesis. Here, we decipher the relationship between FBXW7 and the hallmarks of cancer and discuss the underlying mechanisms. Considering the interplay of cancer hallmarks, we propose several prospective strategies for circumventing the deficits of therapeutic resistance and complete cure of cancer patients. |
| first_indexed | 2024-12-10T04:48:22Z |
| format | Article |
| id | doaj.art-07c2463ce7ee4edca1fa928c19ceb291 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T04:48:22Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-07c2463ce7ee4edca1fa928c19ceb2912022-12-22T02:01:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.880077880077FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective StrategiesWenyue Shen0Wenyue Shen1Quanwei Zhou2Quanwei Zhou3Chenxi Peng4Chenxi Peng5Jiaheng Li6Jiaheng Li7Qizhi Yuan8Qizhi Yuan9Hecheng Zhu10Hecheng Zhu11Ming Zhao12Xingjun Jiang13Xingjun Jiang14Weidong Liu15Weidong Liu16Caiping Ren17Caiping Ren18Caiping Ren19Caiping Ren20Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaCancer Research Institute, School of Basic Medical Science, Central South University, Changsha, ChinaChangsha Kexin Cancer Hospital, Changsha, ChinaChangsha Kexin Cancer Hospital, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaCancer Research Institute, School of Basic Medical Science, Central South University, Changsha, ChinaThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaCancer Research Institute, School of Basic Medical Science, Central South University, Changsha, ChinaThe Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine, Central South University, Changsha, ChinaFBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases especially tumorigenesis. Here, we decipher the relationship between FBXW7 and the hallmarks of cancer and discuss the underlying mechanisms. Considering the interplay of cancer hallmarks, we propose several prospective strategies for circumventing the deficits of therapeutic resistance and complete cure of cancer patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.880077/fullFBXW7hallmarks of cancermetabolic reprogrammingtherapeutic resistancec-MYCmTOR |
| spellingShingle | Wenyue Shen Wenyue Shen Quanwei Zhou Quanwei Zhou Chenxi Peng Chenxi Peng Jiaheng Li Jiaheng Li Qizhi Yuan Qizhi Yuan Hecheng Zhu Hecheng Zhu Ming Zhao Xingjun Jiang Xingjun Jiang Weidong Liu Weidong Liu Caiping Ren Caiping Ren Caiping Ren Caiping Ren FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies Frontiers in Oncology FBXW7 hallmarks of cancer metabolic reprogramming therapeutic resistance c-MYC mTOR |
| title | FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies |
| title_full | FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies |
| title_fullStr | FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies |
| title_full_unstemmed | FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies |
| title_short | FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies |
| title_sort | fbxw7 and the hallmarks of cancer underlying mechanisms and prospective strategies |
| topic | FBXW7 hallmarks of cancer metabolic reprogramming therapeutic resistance c-MYC mTOR |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.880077/full |
| work_keys_str_mv | AT wenyueshen fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT wenyueshen fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT quanweizhou fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT quanweizhou fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT chenxipeng fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT chenxipeng fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT jiahengli fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT jiahengli fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT qizhiyuan fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT qizhiyuan fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT hechengzhu fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT hechengzhu fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT mingzhao fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT xingjunjiang fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT xingjunjiang fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT weidongliu fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT weidongliu fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT caipingren fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT caipingren fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT caipingren fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies AT caipingren fbxw7andthehallmarksofcancerunderlyingmechanismsandprospectivestrategies |