Fatigue in Kidney Transplantation: A Systematic Review and Meta-Analysis
Fatigue is still present in up to 40–50% of kidney transplant recipients (KTR), the results of studies comparing the prevalence among patients on hemodialysis (HD) and KTR led to conflicting results. Fatigue correlates include inflammation, symptoms of depression, sleep disorders and obesity. Fatigu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/5/833 |
| _version_ | 1797535192083070976 |
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| author | Maurizio Bossola Maria Arena Federica Urciuolo Manuela Antocicco Gilda Pepe Giovanna Elisa Calabrò Claudia Cianfrocca Enrico Di Stasio |
| author_facet | Maurizio Bossola Maria Arena Federica Urciuolo Manuela Antocicco Gilda Pepe Giovanna Elisa Calabrò Claudia Cianfrocca Enrico Di Stasio |
| author_sort | Maurizio Bossola |
| collection | DOAJ |
| description | Fatigue is still present in up to 40–50% of kidney transplant recipients (KTR), the results of studies comparing the prevalence among patients on hemodialysis (HD) and KTR led to conflicting results. Fatigue correlates include inflammation, symptoms of depression, sleep disorders and obesity. Fatigue in KTR leads to significant functional impairment, it is common among KTR poorly adherent to immunosuppressive therapy and is associated with a serious deterioration of quality of life. The following databases were searched for relevant studies up to November 2020: Medline, PubMed, Web of Science and the Cochrane Library. Several studies have compared the prevalence and severity of fatigue between KTR and hemodialysis or healthy patients. They have shown that fatigue determines a significant functional deterioration with less chance of having a paid job and a significant change in quality of life. The aim of the review is to report methods to assess fatigue and its prevalence in KTR patients, compared to HD subjects and define the effects of fatigue on health status and daily life. There is no evidence of studies on the treatment of this symptom in KTR. Efforts to identify and treat fatigue should be a priority to improve the quality of life of KTR. |
| first_indexed | 2024-03-10T11:41:03Z |
| format | Article |
| id | doaj.art-07c36f5280fa4ee2b9ca734a2f3eaf7d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T11:41:03Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-07c36f5280fa4ee2b9ca734a2f3eaf7d2023-11-21T18:25:51ZengMDPI AGDiagnostics2075-44182021-05-0111583310.3390/diagnostics11050833Fatigue in Kidney Transplantation: A Systematic Review and Meta-AnalysisMaurizio Bossola0Maria Arena1Federica Urciuolo2Manuela Antocicco3Gilda Pepe4Giovanna Elisa Calabrò5Claudia Cianfrocca6Enrico Di Stasio7Dipartimento di Scienze Mediche e Chirurgiche, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyDipartimento di Scienze Mediche e Chirurgiche, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyDipartimento di Scienze Mediche e Chirurgiche, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, ItalyDipartimento di Scienze Mediche e Chirurgiche, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyDipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Igiene, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyDipartimento di Biomedicina e Prevenzione, Università degli Studi di Roma “Tor Vergata”, 00133 Roma, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, ItalyFatigue is still present in up to 40–50% of kidney transplant recipients (KTR), the results of studies comparing the prevalence among patients on hemodialysis (HD) and KTR led to conflicting results. Fatigue correlates include inflammation, symptoms of depression, sleep disorders and obesity. Fatigue in KTR leads to significant functional impairment, it is common among KTR poorly adherent to immunosuppressive therapy and is associated with a serious deterioration of quality of life. The following databases were searched for relevant studies up to November 2020: Medline, PubMed, Web of Science and the Cochrane Library. Several studies have compared the prevalence and severity of fatigue between KTR and hemodialysis or healthy patients. They have shown that fatigue determines a significant functional deterioration with less chance of having a paid job and a significant change in quality of life. The aim of the review is to report methods to assess fatigue and its prevalence in KTR patients, compared to HD subjects and define the effects of fatigue on health status and daily life. There is no evidence of studies on the treatment of this symptom in KTR. Efforts to identify and treat fatigue should be a priority to improve the quality of life of KTR.https://www.mdpi.com/2075-4418/11/5/833kidney transplant recipientspatients on hemodialysisfatigueassessment |
| spellingShingle | Maurizio Bossola Maria Arena Federica Urciuolo Manuela Antocicco Gilda Pepe Giovanna Elisa Calabrò Claudia Cianfrocca Enrico Di Stasio Fatigue in Kidney Transplantation: A Systematic Review and Meta-Analysis Diagnostics kidney transplant recipients patients on hemodialysis fatigue assessment |
| title | Fatigue in Kidney Transplantation: A Systematic Review and Meta-Analysis |
| title_full | Fatigue in Kidney Transplantation: A Systematic Review and Meta-Analysis |
| title_fullStr | Fatigue in Kidney Transplantation: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Fatigue in Kidney Transplantation: A Systematic Review and Meta-Analysis |
| title_short | Fatigue in Kidney Transplantation: A Systematic Review and Meta-Analysis |
| title_sort | fatigue in kidney transplantation a systematic review and meta analysis |
| topic | kidney transplant recipients patients on hemodialysis fatigue assessment |
| url | https://www.mdpi.com/2075-4418/11/5/833 |
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