Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>Axl, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampen...

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Bibliographic Details
Main Authors: Prieto Anne L, Arnett Heather A, Macian Fernando, Goldberg Michael F, Loudig Olivier, Brosnan Celia F, Weinger Jason G, Tsiperson Vladislav, Shafit-Zagardo Bridget
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/8/1/49

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