From Structural Studies to HCV Vaccine Design
Hepatitis C virus (HCV) is a serious and growing public health problem despite recent developments of antiviral therapeutics. To achieve global elimination of HCV, an effective cross-genotype vaccine is needed. The failure of previous vaccination trials to elicit an effective cross-reactive immune r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/5/833 |
| _version_ | 1797535192303271936 |
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| author | Itai Yechezkel Mansun Law Netanel Tzarum |
| author_facet | Itai Yechezkel Mansun Law Netanel Tzarum |
| author_sort | Itai Yechezkel |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) is a serious and growing public health problem despite recent developments of antiviral therapeutics. To achieve global elimination of HCV, an effective cross-genotype vaccine is needed. The failure of previous vaccination trials to elicit an effective cross-reactive immune response demands better vaccine antigens to induce a potent cross-neutralizing response to improve vaccine efficacy. HCV E1 and E2 envelope (Env) glycoproteins are the main targets for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. Therefore, a molecular-level understanding of the nAb responses against HCV is imperative for the rational design of cross-genotype vaccine antigens. Here we summarize the recent advances in structural studies of HCV Env and Env-nAb complexes and how they improve our understanding of immune recognition of HCV. We review the structural data defining HCV neutralization epitopes and conformational plasticity of the Env proteins, and the knowledge applicable to rational vaccine design. |
| first_indexed | 2024-03-10T11:42:01Z |
| format | Article |
| id | doaj.art-07c625b36fae49c5b835d0d6274001e1 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:42:01Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-07c625b36fae49c5b835d0d6274001e12023-11-21T18:23:38ZengMDPI AGViruses1999-49152021-05-0113583310.3390/v13050833From Structural Studies to HCV Vaccine DesignItai Yechezkel0Mansun Law1Netanel Tzarum2Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Faculty of Mathematics & Science, The Hebrew University of Jerusalem, Jerusalem 9190401, IsraelDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USADepartment of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Faculty of Mathematics & Science, The Hebrew University of Jerusalem, Jerusalem 9190401, IsraelHepatitis C virus (HCV) is a serious and growing public health problem despite recent developments of antiviral therapeutics. To achieve global elimination of HCV, an effective cross-genotype vaccine is needed. The failure of previous vaccination trials to elicit an effective cross-reactive immune response demands better vaccine antigens to induce a potent cross-neutralizing response to improve vaccine efficacy. HCV E1 and E2 envelope (Env) glycoproteins are the main targets for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. Therefore, a molecular-level understanding of the nAb responses against HCV is imperative for the rational design of cross-genotype vaccine antigens. Here we summarize the recent advances in structural studies of HCV Env and Env-nAb complexes and how they improve our understanding of immune recognition of HCV. We review the structural data defining HCV neutralization epitopes and conformational plasticity of the Env proteins, and the knowledge applicable to rational vaccine design.https://www.mdpi.com/1999-4915/13/5/833hepatitis C virus (HCV)neutralizing antibodiesstructural studiesenvelope glycoproteinsE1E2 |
| spellingShingle | Itai Yechezkel Mansun Law Netanel Tzarum From Structural Studies to HCV Vaccine Design Viruses hepatitis C virus (HCV) neutralizing antibodies structural studies envelope glycoproteins E1 E2 |
| title | From Structural Studies to HCV Vaccine Design |
| title_full | From Structural Studies to HCV Vaccine Design |
| title_fullStr | From Structural Studies to HCV Vaccine Design |
| title_full_unstemmed | From Structural Studies to HCV Vaccine Design |
| title_short | From Structural Studies to HCV Vaccine Design |
| title_sort | from structural studies to hcv vaccine design |
| topic | hepatitis C virus (HCV) neutralizing antibodies structural studies envelope glycoproteins E1 E2 |
| url | https://www.mdpi.com/1999-4915/13/5/833 |
| work_keys_str_mv | AT itaiyechezkel fromstructuralstudiestohcvvaccinedesign AT mansunlaw fromstructuralstudiestohcvvaccinedesign AT netaneltzarum fromstructuralstudiestohcvvaccinedesign |