Key Molecular Events in Cervical Cancer Development
Cervical cancer is the fourth most common cancer among women. Infection by high-risk human papillomavirus (HPV) is the main aetiology for the development of cervical cancer. Infection by high-risk human papillomavirus (HPV) and the integration of the HPV genome into the host chromosome of cervical e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/7/384 |
| _version_ | 1797728385322975232 |
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| author | Shandra Devi Balasubramaniam Venugopal Balakrishnan Chern Ein Oon Gurjeet Kaur |
| author_facet | Shandra Devi Balasubramaniam Venugopal Balakrishnan Chern Ein Oon Gurjeet Kaur |
| author_sort | Shandra Devi Balasubramaniam |
| collection | DOAJ |
| description | Cervical cancer is the fourth most common cancer among women. Infection by high-risk human papillomavirus (HPV) is the main aetiology for the development of cervical cancer. Infection by high-risk human papillomavirus (HPV) and the integration of the HPV genome into the host chromosome of cervical epithelial cells are key early events in the neoplastic progression of cervical lesions. The viral oncoproteins, mainly E6 and E7, are responsible for the initial changes in epithelial cells. The viral proteins inactivate two main tumour suppressor proteins, p53, and retinoblastoma (pRb). Inactivation of these host proteins disrupts both the DNA repair mechanisms and apoptosis, leading to rapid cell proliferation. Multiple genes involved in DNA repair, cell proliferation, growth factor activity, angiogenesis, as well as mitogenesis genes become highly expressed in cervical intraepithelial neoplasia (CIN) and cancer. This genomic instability encourages HPV-infected cells to progress towards invasive carcinoma. The key molecular events involved in cervical carcinogenesis will be discussed in this review. |
| first_indexed | 2024-03-12T11:13:11Z |
| format | Article |
| id | doaj.art-07c693456ede4ee382d4d47ea967ae21 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:13:11Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-07c693456ede4ee382d4d47ea967ae212023-09-02T02:28:33ZengMDPI AGMedicina1010-660X2019-07-0155738410.3390/medicina55070384medicina55070384Key Molecular Events in Cervical Cancer DevelopmentShandra Devi Balasubramaniam0Venugopal Balakrishnan1Chern Ein Oon2Gurjeet Kaur3Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, MalaysiaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, MalaysiaCervical cancer is the fourth most common cancer among women. Infection by high-risk human papillomavirus (HPV) is the main aetiology for the development of cervical cancer. Infection by high-risk human papillomavirus (HPV) and the integration of the HPV genome into the host chromosome of cervical epithelial cells are key early events in the neoplastic progression of cervical lesions. The viral oncoproteins, mainly E6 and E7, are responsible for the initial changes in epithelial cells. The viral proteins inactivate two main tumour suppressor proteins, p53, and retinoblastoma (pRb). Inactivation of these host proteins disrupts both the DNA repair mechanisms and apoptosis, leading to rapid cell proliferation. Multiple genes involved in DNA repair, cell proliferation, growth factor activity, angiogenesis, as well as mitogenesis genes become highly expressed in cervical intraepithelial neoplasia (CIN) and cancer. This genomic instability encourages HPV-infected cells to progress towards invasive carcinoma. The key molecular events involved in cervical carcinogenesis will be discussed in this review.https://www.mdpi.com/1010-660X/55/7/384cervical cancercervical intraepithelial neoplasiahuman papillomaviruscarcinogenesisviral oncoproteintumour suppressor gene |
| spellingShingle | Shandra Devi Balasubramaniam Venugopal Balakrishnan Chern Ein Oon Gurjeet Kaur Key Molecular Events in Cervical Cancer Development Medicina cervical cancer cervical intraepithelial neoplasia human papillomavirus carcinogenesis viral oncoprotein tumour suppressor gene |
| title | Key Molecular Events in Cervical Cancer Development |
| title_full | Key Molecular Events in Cervical Cancer Development |
| title_fullStr | Key Molecular Events in Cervical Cancer Development |
| title_full_unstemmed | Key Molecular Events in Cervical Cancer Development |
| title_short | Key Molecular Events in Cervical Cancer Development |
| title_sort | key molecular events in cervical cancer development |
| topic | cervical cancer cervical intraepithelial neoplasia human papillomavirus carcinogenesis viral oncoprotein tumour suppressor gene |
| url | https://www.mdpi.com/1010-660X/55/7/384 |
| work_keys_str_mv | AT shandradevibalasubramaniam keymoleculareventsincervicalcancerdevelopment AT venugopalbalakrishnan keymoleculareventsincervicalcancerdevelopment AT cherneinoon keymoleculareventsincervicalcancerdevelopment AT gurjeetkaur keymoleculareventsincervicalcancerdevelopment |