GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NH<sub>3</sub> Translocation

GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NH<sub>3</sub> Translocation

Cytidine-5′-triphosphate (CTP) synthase (CTPS) is the class I glutamine-dependent amidotransferase (GAT) that catalyzes the last step in the de novo biosynthesis of CTP. Glutamine hydrolysis is catalyzed in the GAT domain and the liberated ammonia is transferred via an intramolecular tunnel to the s...

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Bibliographic Details
Main Authors: Stephen L. Bearne, Chen-Jun Guo, Ji-Long Liu
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomolecules
Subjects:
CTP synthase
allostery
ammonia tunnel
guanosine-5′-triphosphate
kinetics
structure
Online Access:https://www.mdpi.com/2218-273X/12/5/647

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