Potential role of sirtuins in livestock production
Sirtuins are NAD+-dependent histone and protein deacetylases, which have been studied during the last decade with a focus on their role in lifespan extension and age-related diseases under normal and calorie-restricted or pathological conditions. However, sirtuins also have the ability to regulate e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Animal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1751731112001115 |
| _version_ | 1818442125803520000 |
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| author | Y. Ghinis-Hozumi A. Antaramian F. Villarroya E. Piña O. Mora |
| author_facet | Y. Ghinis-Hozumi A. Antaramian F. Villarroya E. Piña O. Mora |
| author_sort | Y. Ghinis-Hozumi |
| collection | DOAJ |
| description | Sirtuins are NAD+-dependent histone and protein deacetylases, which have been studied during the last decade with a focus on their role in lifespan extension and age-related diseases under normal and calorie-restricted or pathological conditions. However, sirtuins also have the ability to regulate energy homeostasis as they can sense the metabolic state of the cell through the NAD+/NADH ratio; hence, changes in the diet can modify the expression of these enzymes. Dietary manipulations are a common practice currently being used in livestock production with favorable results, probably due in part to the enhanced activity of sirtuins. Nevertheless, sirtuin expression in livestock species has not been a research target. For these reasons, the goal of this review is to awaken interest in these enzymes for future detailed characterization in livestock species by presenting a general introduction to what sirtuins are, how they work and what is known about their role in livestock. |
| first_indexed | 2024-12-14T18:39:11Z |
| format | Article |
| id | doaj.art-07c7c1bc13ad48c6ab60fecdc11be552 |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-12-14T18:39:11Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Animal |
| spelling | doaj.art-07c7c1bc13ad48c6ab60fecdc11be5522022-12-21T22:51:32ZengElsevierAnimal1751-73112013-01-0171101108Potential role of sirtuins in livestock productionY. Ghinis-Hozumi0A. Antaramian1F. Villarroya2E. Piña3O. Mora4Programa de Posgrado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, MéxicoInstituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Querétaro, Qro. 76230, MéxicoDepartamento de Bioquímica y Biología Molecular e Instituto de Biomedicina (IBUB), Universitat de Barcelona y Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Avenida Diagonal 645, Barcelona 08028, SpainDepartamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MéxicoLaboratorio de Rumiología y Metabolismo Nutricional (RuMeN), Secretaría de Posgrado, Facultad de Estudios Superiores-Cuautitlán, Universidad Nacional Autónoma de México, Boulevard Bernardo Quintana 514-D, Colonia Arboledas, Querétaro, Qro. 76140, MéxicoSirtuins are NAD+-dependent histone and protein deacetylases, which have been studied during the last decade with a focus on their role in lifespan extension and age-related diseases under normal and calorie-restricted or pathological conditions. However, sirtuins also have the ability to regulate energy homeostasis as they can sense the metabolic state of the cell through the NAD+/NADH ratio; hence, changes in the diet can modify the expression of these enzymes. Dietary manipulations are a common practice currently being used in livestock production with favorable results, probably due in part to the enhanced activity of sirtuins. Nevertheless, sirtuin expression in livestock species has not been a research target. For these reasons, the goal of this review is to awaken interest in these enzymes for future detailed characterization in livestock species by presenting a general introduction to what sirtuins are, how they work and what is known about their role in livestock.http://www.sciencedirect.com/science/article/pii/S1751731112001115energylivestockmetabolismproductionsirtuin |
| spellingShingle | Y. Ghinis-Hozumi A. Antaramian F. Villarroya E. Piña O. Mora Potential role of sirtuins in livestock production Animal energy livestock metabolism production sirtuin |
| title | Potential role of sirtuins in livestock production |
| title_full | Potential role of sirtuins in livestock production |
| title_fullStr | Potential role of sirtuins in livestock production |
| title_full_unstemmed | Potential role of sirtuins in livestock production |
| title_short | Potential role of sirtuins in livestock production |
| title_sort | potential role of sirtuins in livestock production |
| topic | energy livestock metabolism production sirtuin |
| url | http://www.sciencedirect.com/science/article/pii/S1751731112001115 |
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