Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.)
Chromatographic purification of the alcoholic extract from the aerial parts of the Saudi plant <i>Nuxia oppositifolia</i> (Hochst.), Benth., resulted in five isolated phenolic compounds. Two flavones, hispidulin (<b>1</b>) and jaceosidin (<b>2</b>), and the phenyl...
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MDPI AG
2021-02-01
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| Online Access: | https://www.mdpi.com/1420-3049/26/4/914 |
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| author | Shaza M. Al-Massarani Ali A. El-Gamal Adnan J. Al-Rehaily Ebtesam S. Al-Sheddi Mai M. Al-Oqail Nida N. Farshori Alden S. Estep Nurhayat Tabanca James J. Becnel |
| author_facet | Shaza M. Al-Massarani Ali A. El-Gamal Adnan J. Al-Rehaily Ebtesam S. Al-Sheddi Mai M. Al-Oqail Nida N. Farshori Alden S. Estep Nurhayat Tabanca James J. Becnel |
| author_sort | Shaza M. Al-Massarani |
| collection | DOAJ |
| description | Chromatographic purification of the alcoholic extract from the aerial parts of the Saudi plant <i>Nuxia oppositifolia</i> (Hochst.), Benth., resulted in five isolated phenolic compounds. Two flavones, hispidulin (<b>1</b>) and jaceosidin (<b>2</b>), and the phenylethanoid glycosides, verbascoside (<b>3</b>), isoverbascoside (<b>4</b>), and conandroside (<b>5</b>), were identified and their chemical structures were determined by spectroscopic analyses. The insecticidal activity of compounds <b>1</b> and <b>2,</b> in addition to 11 compounds isolated in a previous research (<b>6</b>–<b>16</b>), was evaluated against the Yellow Fever mosquito, <i>Aedes aegypti</i>. Four compounds displayed adulticidal activity with LD<sub>50</sub> values of 2–2.3 μg/mosquito. Free radical scavenging properties of the plant extracts and compounds (<b>1</b>–<b>5</b>) were evaluated by measuring the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonate radical cation (ABTS<sup>•+</sup>) scavenging activity. All compounds exhibited notable activity, compared with the positive control, <span style="font-variant: small-caps;">l</span>-Ascorbic acid. This study suggests that <i>N. oppositifolia</i> could be a promising source of secondary metabolites, some with lethal adulticidal effect against <i>Ae. aegypti</i>. |
| first_indexed | 2024-03-09T04:58:43Z |
| format | Article |
| id | doaj.art-07c8e3c49cfd4dcb85621980a8a5e81d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:58:43Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-07c8e3c49cfd4dcb85621980a8a5e81d2023-12-03T13:01:44ZengMDPI AGMolecules1420-30492021-02-0126491410.3390/molecules26040914Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.)Shaza M. Al-Massarani0Ali A. El-Gamal1Adnan J. Al-Rehaily2Ebtesam S. Al-Sheddi3Mai M. Al-Oqail4Nida N. Farshori5Alden S. Estep6Nurhayat Tabanca7James J. Becnel8Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaUSDA, ARS, Center for Medical, Agricultural, and Veterinary Entomology, Gainesville, FL 32608, USAUSDA-ARS, Subtropical Horticulture Research Station, 13601 Old Cutler Rd., Miami, FL 33158, USAUSDA, ARS, Center for Medical, Agricultural, and Veterinary Entomology, Gainesville, FL 32608, USAChromatographic purification of the alcoholic extract from the aerial parts of the Saudi plant <i>Nuxia oppositifolia</i> (Hochst.), Benth., resulted in five isolated phenolic compounds. Two flavones, hispidulin (<b>1</b>) and jaceosidin (<b>2</b>), and the phenylethanoid glycosides, verbascoside (<b>3</b>), isoverbascoside (<b>4</b>), and conandroside (<b>5</b>), were identified and their chemical structures were determined by spectroscopic analyses. The insecticidal activity of compounds <b>1</b> and <b>2,</b> in addition to 11 compounds isolated in a previous research (<b>6</b>–<b>16</b>), was evaluated against the Yellow Fever mosquito, <i>Aedes aegypti</i>. Four compounds displayed adulticidal activity with LD<sub>50</sub> values of 2–2.3 μg/mosquito. Free radical scavenging properties of the plant extracts and compounds (<b>1</b>–<b>5</b>) were evaluated by measuring the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonate radical cation (ABTS<sup>•+</sup>) scavenging activity. All compounds exhibited notable activity, compared with the positive control, <span style="font-variant: small-caps;">l</span>-Ascorbic acid. This study suggests that <i>N. oppositifolia</i> could be a promising source of secondary metabolites, some with lethal adulticidal effect against <i>Ae. aegypti</i>.https://www.mdpi.com/1420-3049/26/4/914<i>Nuxia oppositifolia</i>flavonoidsphenylethanoidtriterpenesmosquito controlbiopesticides |
| spellingShingle | Shaza M. Al-Massarani Ali A. El-Gamal Adnan J. Al-Rehaily Ebtesam S. Al-Sheddi Mai M. Al-Oqail Nida N. Farshori Alden S. Estep Nurhayat Tabanca James J. Becnel Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.) Molecules <i>Nuxia oppositifolia</i> flavonoids phenylethanoid triterpenes mosquito control biopesticides |
| title | Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.) |
| title_full | Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.) |
| title_fullStr | Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.) |
| title_full_unstemmed | Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.) |
| title_short | Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant <i>Nuxia oppositifolia</i> (Hochst.) |
| title_sort | insecticidal activity and free radical scavenging properties of isolated phytoconstituents from the saudi plant i nuxia oppositifolia i hochst |
| topic | <i>Nuxia oppositifolia</i> flavonoids phenylethanoid triterpenes mosquito control biopesticides |
| url | https://www.mdpi.com/1420-3049/26/4/914 |
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