In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites
The present study aims to evaluate effect of hydroxyapatite (HA, Ca10(PO4)6OH2), a ceramic similar to natural bone, into AZ31B Mg alloy matrix on biomineralization and biocompatibility. The novel friction stir processing additive manufacturing route was employed to fabricate Mg-HA composites. Variou...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2020-12-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X20301006 |
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| author | Yee-Hsien Ho Kun Man Sameehan S. Joshi Mangesh V. Pantawane Tso-Chang Wu Yong Yang Narendra B. Dahotre |
| author_facet | Yee-Hsien Ho Kun Man Sameehan S. Joshi Mangesh V. Pantawane Tso-Chang Wu Yong Yang Narendra B. Dahotre |
| author_sort | Yee-Hsien Ho |
| collection | DOAJ |
| description | The present study aims to evaluate effect of hydroxyapatite (HA, Ca10(PO4)6OH2), a ceramic similar to natural bone, into AZ31B Mg alloy matrix on biomineralization and biocompatibility. The novel friction stir processing additive manufacturing route was employed to fabricate Mg-HA composites. Various HA contents (5, 10, 20 wt%) were incorporated into Mg matrix.Microstructural observation and chemical composition analysis revealed that refined Mg grains and dispersion of HA particles at micro/nanoscales were achieved in Mg-HA composites after the friction stir processing. The biomineralization evaluation were carried out using immersion experiments in simulated body fluid followed by mineral morphology observation and chemical composition analysis. The wettability measurements were conducted to correlate the biomineralization behavior. The results showed improvement in wettability and bone-like Ca/P ratio in apatite deposit on the composites compared to as-received Mg. In addition, the increase of blood compatibility, cell viability and spreading were found in the higher HA content composites, indicating the improved biocompatibility. Therefore, friction stir processed Mg-20 wt%HA composite exhibited the highest wettability and better cell adhesion among other composites due to the effect of increased HA content within Mg matrix. |
| first_indexed | 2024-04-24T08:27:35Z |
| format | Article |
| id | doaj.art-07c8ff5c13aa471884b1ac849139a4c0 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:27:35Z |
| publishDate | 2020-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-07c8ff5c13aa471884b1ac849139a4c02024-04-16T21:06:57ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2020-12-0154891901In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite compositesYee-Hsien Ho0Kun Man1Sameehan S. Joshi2Mangesh V. Pantawane3Tso-Chang Wu4Yong Yang5Narendra B. Dahotre6Laboratory for Laser Aided Additive and Subtractive Manufacturing, Department of Materials Science and Engineering, University of North Texas, 1150 Union Circle 305310, Denton, TX, 76203-5017, USADepartment of Biomedical Engineering, University of North Texas, 1150 Union Circle 305310, Denton, TX, 76203-5017, USALaboratory for Laser Aided Additive and Subtractive Manufacturing, Department of Materials Science and Engineering, University of North Texas, 1150 Union Circle 305310, Denton, TX, 76203-5017, USALaboratory for Laser Aided Additive and Subtractive Manufacturing, Department of Materials Science and Engineering, University of North Texas, 1150 Union Circle 305310, Denton, TX, 76203-5017, USALaboratory for Laser Aided Additive and Subtractive Manufacturing, Department of Materials Science and Engineering, University of North Texas, 1150 Union Circle 305310, Denton, TX, 76203-5017, USADepartment of Biomedical Engineering, University of North Texas, 1150 Union Circle 305310, Denton, TX, 76203-5017, USALaboratory for Laser Aided Additive and Subtractive Manufacturing, Department of Materials Science and Engineering, University of North Texas, 1150 Union Circle 305310, Denton, TX, 76203-5017, USA; Corresponding author.The present study aims to evaluate effect of hydroxyapatite (HA, Ca10(PO4)6OH2), a ceramic similar to natural bone, into AZ31B Mg alloy matrix on biomineralization and biocompatibility. The novel friction stir processing additive manufacturing route was employed to fabricate Mg-HA composites. Various HA contents (5, 10, 20 wt%) were incorporated into Mg matrix.Microstructural observation and chemical composition analysis revealed that refined Mg grains and dispersion of HA particles at micro/nanoscales were achieved in Mg-HA composites after the friction stir processing. The biomineralization evaluation were carried out using immersion experiments in simulated body fluid followed by mineral morphology observation and chemical composition analysis. The wettability measurements were conducted to correlate the biomineralization behavior. The results showed improvement in wettability and bone-like Ca/P ratio in apatite deposit on the composites compared to as-received Mg. In addition, the increase of blood compatibility, cell viability and spreading were found in the higher HA content composites, indicating the improved biocompatibility. Therefore, friction stir processed Mg-20 wt%HA composite exhibited the highest wettability and better cell adhesion among other composites due to the effect of increased HA content within Mg matrix.http://www.sciencedirect.com/science/article/pii/S2452199X20301006Friction stir processingMagnesium alloyHydroxyapatiteAdditive manufacturingBiomineralizationContact angle measurement |
| spellingShingle | Yee-Hsien Ho Kun Man Sameehan S. Joshi Mangesh V. Pantawane Tso-Chang Wu Yong Yang Narendra B. Dahotre In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites Bioactive Materials Friction stir processing Magnesium alloy Hydroxyapatite Additive manufacturing Biomineralization Contact angle measurement |
| title | In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites |
| title_full | In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites |
| title_fullStr | In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites |
| title_full_unstemmed | In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites |
| title_short | In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites |
| title_sort | in vitro biomineralization and biocompatibility of friction stir additively manufactured az31b magnesium alloy hydroxyapatite composites |
| topic | Friction stir processing Magnesium alloy Hydroxyapatite Additive manufacturing Biomineralization Contact angle measurement |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X20301006 |
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