DNA Methylation Analysis in Plasma Cell-Free DNA and Paired CTCs of NSCLC Patients before and after Osimertinib Treatment

DNA Methylation Analysis in Plasma Cell-Free DNA and Paired CTCs of NSCLC Patients before and after Osimertinib Treatment

Osimertinib has been an effective second-line treatment in EGFR mutant NSCLC patients; however, resistance inevitably occurs. DNA methylation has been previously implicated in NSCLC progression and often in therapy resistance, however its distinct role in osimertinib resistance is not elucidated as...

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Bibliographic Details
Main Authors: Aliki Ntzifa, Dora Londra, Theodoros Rampias, Athanasios Kotsakis, Vassilis Georgoulias, Evi Lianidou
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
DNA methylation
liquid biopsy
circulating tumor cells
cell-free DNA
NSCLC
osimertinib
Online Access:https://www.mdpi.com/2072-6694/13/23/5974

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