Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolism
ABSTRACT: Glyphosate-based herbicides (GBH) are the most commonly used herbicides in agriculture. Several studies reported possible adverse effects on human and animal models after a GBH exposure. However, the effects of a temporary maternal exposure on the progeny have been poorly documented, espec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579123003966 |
| _version_ | 1797738973742759936 |
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| author | Anthony Estienne Mathias Fréville Ophélie Bernardi Christelle Ramé Ludovic Calandreau Fabien Cornilleau Patrice Ganier Marine Chahnamian Pascal Froment Joëlle Dupont |
| author_facet | Anthony Estienne Mathias Fréville Ophélie Bernardi Christelle Ramé Ludovic Calandreau Fabien Cornilleau Patrice Ganier Marine Chahnamian Pascal Froment Joëlle Dupont |
| author_sort | Anthony Estienne |
| collection | DOAJ |
| description | ABSTRACT: Glyphosate-based herbicides (GBH) are the most commonly used herbicides in agriculture. Several studies reported possible adverse effects on human and animal models after a GBH exposure. However, the effects of a temporary maternal exposure on the progeny have been poorly documented, especially in avian models. We investigated the effects of a hen chronic dietary exposure to a GBH on the progeny, obtained during the period following the withdrawal of GBH from the diet. Hens were exposed to a GBH via their food for 6 wk, after which the GBH was removed from their food. Eggs from these hens were collected 3 wk after the GBH was withdrawn for 1 wk. We monitored the growth performances, metabolic parameters, and behavior from the progeny of the hens (Ex-GBH chicks, n = 186) and compared them with those of unexposed control-hen progeny (CT chicks, n = 213). Ex-GBH chicks were more likely to explore their new environment than CT chicks during the open-field test. In addition, they had an increased fattening and blood triglycerides level, whereas their food consumption was similar to CT chicks. Quantitative PCR on the chemerin system and FASN in chicks livers indicate a transcriptional activity in favor of fatty acid synthesis, and lipidomic analysis on chicks abdominal adipose tissue reveal a global increase in monounsaturated fatty acid and a global decrease in polyunsaturated fatty acids. Seven genes involved in the synthesis of fatty acids were identified with the open access LIPIDMAP software, and their disturbance in Ex-GBH chicks was confirmed via qPCR. Taken together, these results suggest that the progeny of hens temporarily exposed to a GBH are more likely to fatten, even with a balanced diet. The removal of GBH from their contaminated environment would therefore not be sufficient to completely restore their health, has it could induce transgenerational effects. |
| first_indexed | 2024-03-12T13:50:35Z |
| format | Article |
| id | doaj.art-07c94a0d6d834ad6a1e67676d1171ee3 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-03-12T13:50:35Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-07c94a0d6d834ad6a1e67676d1171ee32023-08-23T04:32:39ZengElsevierPoultry Science0032-57912023-09-011029102877Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolismAnthony Estienne0Mathias Fréville1Ophélie Bernardi2Christelle Ramé3Ludovic Calandreau4Fabien Cornilleau5Patrice Ganier6Marine Chahnamian7Pascal Froment8Joëlle Dupont9CNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, FranceCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, FranceCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, France; SYSAAF, Syndicat des Sélectionneurs Avicoles et Aquacoles Français, Centre INRA Val de Loire, Nouzilly, 37380, FranceCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, FranceCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, FranceCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, FranceINRAE - Unité Expérimentale du Pôle d'Expérimentation Avicole de Tours UEPEAT 1295, Nouzilly, F-37380, FranceINRAE - Unité Expérimentale du Pôle d'Expérimentation Avicole de Tours UEPEAT 1295, Nouzilly, F-37380, FranceCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, FranceCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, F-37380, France; Corresponding author:ABSTRACT: Glyphosate-based herbicides (GBH) are the most commonly used herbicides in agriculture. Several studies reported possible adverse effects on human and animal models after a GBH exposure. However, the effects of a temporary maternal exposure on the progeny have been poorly documented, especially in avian models. We investigated the effects of a hen chronic dietary exposure to a GBH on the progeny, obtained during the period following the withdrawal of GBH from the diet. Hens were exposed to a GBH via their food for 6 wk, after which the GBH was removed from their food. Eggs from these hens were collected 3 wk after the GBH was withdrawn for 1 wk. We monitored the growth performances, metabolic parameters, and behavior from the progeny of the hens (Ex-GBH chicks, n = 186) and compared them with those of unexposed control-hen progeny (CT chicks, n = 213). Ex-GBH chicks were more likely to explore their new environment than CT chicks during the open-field test. In addition, they had an increased fattening and blood triglycerides level, whereas their food consumption was similar to CT chicks. Quantitative PCR on the chemerin system and FASN in chicks livers indicate a transcriptional activity in favor of fatty acid synthesis, and lipidomic analysis on chicks abdominal adipose tissue reveal a global increase in monounsaturated fatty acid and a global decrease in polyunsaturated fatty acids. Seven genes involved in the synthesis of fatty acids were identified with the open access LIPIDMAP software, and their disturbance in Ex-GBH chicks was confirmed via qPCR. Taken together, these results suggest that the progeny of hens temporarily exposed to a GBH are more likely to fatten, even with a balanced diet. The removal of GBH from their contaminated environment would therefore not be sufficient to completely restore their health, has it could induce transgenerational effects.http://www.sciencedirect.com/science/article/pii/S0032579123003966glyphosatehen exposurechickfatteningbehavior |
| spellingShingle | Anthony Estienne Mathias Fréville Ophélie Bernardi Christelle Ramé Ludovic Calandreau Fabien Cornilleau Patrice Ganier Marine Chahnamian Pascal Froment Joëlle Dupont Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolism Poultry Science glyphosate hen exposure chick fattening behavior |
| title | Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolism |
| title_full | Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolism |
| title_fullStr | Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolism |
| title_full_unstemmed | Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolism |
| title_short | Chronic dietary exposure to a glyphosate-based herbicide in broiler hens has long-term impacts on the progeny metabolism |
| title_sort | chronic dietary exposure to a glyphosate based herbicide in broiler hens has long term impacts on the progeny metabolism |
| topic | glyphosate hen exposure chick fattening behavior |
| url | http://www.sciencedirect.com/science/article/pii/S0032579123003966 |
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