Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults
Introduction Annual cognitive screening in older adults is essential for early detection of cognitive impairment, yet primary care settings face time constraints that present barriers to routine screening. A remote cognitive screener completed on a patient’s personal smartphone before a visit has th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/4/e083612.full |
| _version_ | 1797226735383609344 |
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| author | Michael Wolf Laura M Curtis Richard Gershon Julia Yoshino Benavente Greg J Byrne Maria Varela Diaz Lihua Yao Cindy Nowinski Stephanie Ruth Young Elizabeth McManus Dworak Callie Madison Jones |
| author_facet | Michael Wolf Laura M Curtis Richard Gershon Julia Yoshino Benavente Greg J Byrne Maria Varela Diaz Lihua Yao Cindy Nowinski Stephanie Ruth Young Elizabeth McManus Dworak Callie Madison Jones |
| author_sort | Michael Wolf |
| collection | DOAJ |
| description | Introduction Annual cognitive screening in older adults is essential for early detection of cognitive impairment, yet primary care settings face time constraints that present barriers to routine screening. A remote cognitive screener completed on a patient’s personal smartphone before a visit has the potential to save primary care clinics time, encourage broader screening practices and increase early detection of cognitive decline. MyCog Mobile is a promising new remote smartphone-based cognitive screening app for primary care settings. We propose a combined construct and clinical validation study of MyCog Mobile.Methods and analysis We will recruit a total sample of 300 adult participants aged 65 years and older. A subsample of 200 healthy adult participants and a subsample of 100 adults with a cognitive impairment diagnosis (ie, dementia, mild cognitive impairment, cognitive deficits or other memory loss) will be recruited from the general population and specialty memory care centres, respectively. To evaluate the construct validity of MyCog Mobile, the healthy control sample will self-administer MyCog Mobile on study-provided smartphones and be administered a battery of gold-standard neuropsychological assessments. We will compare correlations between performance on MyCog Mobile and measures of similar and dissimilar constructs to evaluate convergent and discriminant validity. To assess clinical validity, participants in the clinical sample will self-administer MyCog Mobile on a smartphone and be administered a Mini-Cog screener and these data will be combined with the healthy control sample. We will then apply several supervised model types to determine the best predictors of cognitive impairment within the sample. Area under the receiver operating characteristic curve, accuracy, sensitivity and specificity will be the primary performance metrics for clinical validity.Ethics and dissemination The Institutional Review Board at Northwestern University (STU00214921) approved this study protocol. Results will be published in peer-reviewed journals and summaries provided to the study’s funders. |
| first_indexed | 2024-04-24T14:29:38Z |
| format | Article |
| id | doaj.art-07ca0989014d45bf9a8a786103a8d023 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-24T14:29:38Z |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-07ca0989014d45bf9a8a786103a8d0232024-04-03T03:55:08ZengBMJ Publishing GroupBMJ Open2044-60552024-04-0114410.1136/bmjopen-2023-083612Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adultsMichael Wolf0Laura M Curtis1Richard Gershon2Julia Yoshino Benavente3Greg J Byrne4Maria Varela Diaz5Lihua Yao6Cindy Nowinski7Stephanie Ruth Young8Elizabeth McManus Dworak9Callie Madison Jones10General Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USACenter for Applied Health Research on Aging, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA14Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USAGeneral Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USAMedical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USAMedical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USAMedical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USAMedical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USADepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USADepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USADepartment of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USAIntroduction Annual cognitive screening in older adults is essential for early detection of cognitive impairment, yet primary care settings face time constraints that present barriers to routine screening. A remote cognitive screener completed on a patient’s personal smartphone before a visit has the potential to save primary care clinics time, encourage broader screening practices and increase early detection of cognitive decline. MyCog Mobile is a promising new remote smartphone-based cognitive screening app for primary care settings. We propose a combined construct and clinical validation study of MyCog Mobile.Methods and analysis We will recruit a total sample of 300 adult participants aged 65 years and older. A subsample of 200 healthy adult participants and a subsample of 100 adults with a cognitive impairment diagnosis (ie, dementia, mild cognitive impairment, cognitive deficits or other memory loss) will be recruited from the general population and specialty memory care centres, respectively. To evaluate the construct validity of MyCog Mobile, the healthy control sample will self-administer MyCog Mobile on study-provided smartphones and be administered a battery of gold-standard neuropsychological assessments. We will compare correlations between performance on MyCog Mobile and measures of similar and dissimilar constructs to evaluate convergent and discriminant validity. To assess clinical validity, participants in the clinical sample will self-administer MyCog Mobile on a smartphone and be administered a Mini-Cog screener and these data will be combined with the healthy control sample. We will then apply several supervised model types to determine the best predictors of cognitive impairment within the sample. Area under the receiver operating characteristic curve, accuracy, sensitivity and specificity will be the primary performance metrics for clinical validity.Ethics and dissemination The Institutional Review Board at Northwestern University (STU00214921) approved this study protocol. Results will be published in peer-reviewed journals and summaries provided to the study’s funders.https://bmjopen.bmj.com/content/14/4/e083612.full |
| spellingShingle | Michael Wolf Laura M Curtis Richard Gershon Julia Yoshino Benavente Greg J Byrne Maria Varela Diaz Lihua Yao Cindy Nowinski Stephanie Ruth Young Elizabeth McManus Dworak Callie Madison Jones Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults BMJ Open |
| title | Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults |
| title_full | Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults |
| title_fullStr | Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults |
| title_full_unstemmed | Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults |
| title_short | Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults |
| title_sort | protocol for a construct and clinical validation study of mycog mobile a remote smartphone based cognitive screener for older adults |
| url | https://bmjopen.bmj.com/content/14/4/e083612.full |
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