Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity.

Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity.

BACKGROUND: Mounting evidence shows that urate may become a biomarker of Parkinson's disease (PD) diagnosis and prognosis and a neuroprotectant candidate for PD therapy. However, the cellular and molecular mechanisms underlying its neuroprotective actions remain poorly understood. RESULTS: In t...

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Bibliographic Details
Main Authors: Ning Zhang, Hai-Yang Shu, Tingting Huang, Qi-Lin Zhang, Da Li, Guan-Qun Zhang, Xiao-Yan Peng, Chun-Feng Liu, Wei-Feng Luo, Li-Fang Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4069024?pdf=render

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