The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review
The history of Lynch syndrome changed definitively in 2000, when a study published in Gastroenterology demonstrated a significant reduction in mortality among individuals with Lynch syndrome who undergo regular endoscopic surveillance. As a consequence of this clinical evidence, all scientific socie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/15/3780 |
| _version_ | 1797586993514807296 |
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| author | Valentina D’Angelo Daniela Rega Pietro Marone Elena Di Girolamo Corrado Civiletti Fabiana Tatangelo Francesca Duraturo Marina De Rosa Mario de Bellis Paolo Delrio |
| author_facet | Valentina D’Angelo Daniela Rega Pietro Marone Elena Di Girolamo Corrado Civiletti Fabiana Tatangelo Francesca Duraturo Marina De Rosa Mario de Bellis Paolo Delrio |
| author_sort | Valentina D’Angelo |
| collection | DOAJ |
| description | The history of Lynch syndrome changed definitively in 2000, when a study published in Gastroenterology demonstrated a significant reduction in mortality among individuals with Lynch syndrome who undergo regular endoscopic surveillance. As a consequence of this clinical evidence, all scientific societies developed guidelines, which highlighted the role of colonoscopy in the management of Lynch syndrome, especially for individuals at high risk of colorectal cancer. Over the years, these guidelines were modified and updated. Specialized networks were developed in order to standardize endoscopic surveillance programs and evaluate all the clinical data retrieved by the results of colonoscopies performed for both the screening and the surveillance of individuals with Lynch syndrome. Recent data show that the impact of colonoscopy (with polypectomy) on the prevention of colorectal cancer in individuals with Lynch syndrome is less significant than previously thought. This narrative review summarizes the current discussion, the hypotheses elaborated and the algorithms depicted for the management of individuals with Lynch Syndrome on the basis of the recent data published in the literature. |
| first_indexed | 2024-03-11T00:29:58Z |
| format | Article |
| id | doaj.art-07cb12e2b1a4473aa6d2acbfd0e0ec34 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:29:58Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-07cb12e2b1a4473aa6d2acbfd0e0ec342023-11-18T22:41:20ZengMDPI AGCancers2072-66942023-07-011515378010.3390/cancers15153780The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative ReviewValentina D’Angelo0Daniela Rega1Pietro Marone2Elena Di Girolamo3Corrado Civiletti4Fabiana Tatangelo5Francesca Duraturo6Marina De Rosa7Mario de Bellis8Paolo Delrio9Division of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyColorectal Surgical Oncology, Department of Abdominal Oncology, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyDivision of AnatomicPathology and Cytopathology, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyDepartment of Molecular Medicine and Biomedical Technology, School of Medicine, University Federico II, 80138 Naples, ItalyDepartment of Molecular Medicine and Biomedical Technology, School of Medicine, University Federico II, 80138 Naples, ItalyDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyColorectal Surgical Oncology, Department of Abdominal Oncology, Istituto Nazionale Tumori-IRCCS “Fondazione G. Pascale”, 80131 Naples, ItalyThe history of Lynch syndrome changed definitively in 2000, when a study published in Gastroenterology demonstrated a significant reduction in mortality among individuals with Lynch syndrome who undergo regular endoscopic surveillance. As a consequence of this clinical evidence, all scientific societies developed guidelines, which highlighted the role of colonoscopy in the management of Lynch syndrome, especially for individuals at high risk of colorectal cancer. Over the years, these guidelines were modified and updated. Specialized networks were developed in order to standardize endoscopic surveillance programs and evaluate all the clinical data retrieved by the results of colonoscopies performed for both the screening and the surveillance of individuals with Lynch syndrome. Recent data show that the impact of colonoscopy (with polypectomy) on the prevention of colorectal cancer in individuals with Lynch syndrome is less significant than previously thought. This narrative review summarizes the current discussion, the hypotheses elaborated and the algorithms depicted for the management of individuals with Lynch Syndrome on the basis of the recent data published in the literature.https://www.mdpi.com/2072-6694/15/15/3780Lynch syndromecolonoscopysurveillancecolorectal cancerincident cancer riskmismatch-repair deficiency |
| spellingShingle | Valentina D’Angelo Daniela Rega Pietro Marone Elena Di Girolamo Corrado Civiletti Fabiana Tatangelo Francesca Duraturo Marina De Rosa Mario de Bellis Paolo Delrio The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review Cancers Lynch syndrome colonoscopy surveillance colorectal cancer incident cancer risk mismatch-repair deficiency |
| title | The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review |
| title_full | The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review |
| title_fullStr | The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review |
| title_full_unstemmed | The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review |
| title_short | The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review |
| title_sort | role of colonoscopy in the management of individuals with lynch syndrome a narrative review |
| topic | Lynch syndrome colonoscopy surveillance colorectal cancer incident cancer risk mismatch-repair deficiency |
| url | https://www.mdpi.com/2072-6694/15/15/3780 |
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