Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease.
Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3940927?pdf=render |
| _version_ | 1819229948060106752 |
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| author | Lars Frings Belinda Yew Emma Flanagan Bonnie Y K Lam Michael Hüll Hans-Jürgen Huppertz John R Hodges Michael Hornberger |
| author_facet | Lars Frings Belinda Yew Emma Flanagan Bonnie Y K Lam Michael Hüll Hans-Jürgen Huppertz John R Hodges Michael Hornberger |
| author_sort | Lars Frings |
| collection | DOAJ |
| description | Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, observer-independent atlas-based MRI volumetry was applied to analyse 102 MRI data sets from 15 bvFTD, 14 AD, and 10 healthy elderly control participants with consecutive scans over at least 12 months. Anatomically defined targets were chosen a priori as brain structures of interest. Groups were compared regarding volumes at clinic presentation and annual change rates. Baseline volumes, especially of grey matter compartments, were significantly reduced in bvFTD and AD patients. Grey matter volumes of the caudate and the gyrus rectus were significantly smaller in bvFTD than AD. The bvFTD group could be separated from AD on the basis of caudate volume with high accuracy (79% cases correct). Annual volume decline was markedly larger in bvFTD and AD than controls, predominantly in white matter of temporal structures. Decline in grey matter volume of the lateral orbitofrontal gyrus separated bvFTD from AD and controls. Automated longitudinal MRI volumetry discriminates bvFTD from AD. In particular, greater reduction of orbitofrontal grey matter and temporal white matter structures after 12 months is indicative of bvFTD. |
| first_indexed | 2024-12-23T11:21:17Z |
| format | Article |
| id | doaj.art-07cb23db16404f86b4e4f77c30191232 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T11:21:17Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-07cb23db16404f86b4e4f77c301912322022-12-21T17:49:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9081410.1371/journal.pone.0090814Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease.Lars FringsBelinda YewEmma FlanaganBonnie Y K LamMichael HüllHans-Jürgen HuppertzJohn R HodgesMichael HornbergerBehavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, observer-independent atlas-based MRI volumetry was applied to analyse 102 MRI data sets from 15 bvFTD, 14 AD, and 10 healthy elderly control participants with consecutive scans over at least 12 months. Anatomically defined targets were chosen a priori as brain structures of interest. Groups were compared regarding volumes at clinic presentation and annual change rates. Baseline volumes, especially of grey matter compartments, were significantly reduced in bvFTD and AD patients. Grey matter volumes of the caudate and the gyrus rectus were significantly smaller in bvFTD than AD. The bvFTD group could be separated from AD on the basis of caudate volume with high accuracy (79% cases correct). Annual volume decline was markedly larger in bvFTD and AD than controls, predominantly in white matter of temporal structures. Decline in grey matter volume of the lateral orbitofrontal gyrus separated bvFTD from AD and controls. Automated longitudinal MRI volumetry discriminates bvFTD from AD. In particular, greater reduction of orbitofrontal grey matter and temporal white matter structures after 12 months is indicative of bvFTD.http://europepmc.org/articles/PMC3940927?pdf=render |
| spellingShingle | Lars Frings Belinda Yew Emma Flanagan Bonnie Y K Lam Michael Hüll Hans-Jürgen Huppertz John R Hodges Michael Hornberger Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease. PLoS ONE |
| title | Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease. |
| title_full | Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease. |
| title_fullStr | Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease. |
| title_full_unstemmed | Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease. |
| title_short | Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease. |
| title_sort | longitudinal grey and white matter changes in frontotemporal dementia and alzheimer s disease |
| url | http://europepmc.org/articles/PMC3940927?pdf=render |
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