Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal

Background: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. Aims and Objectives: We have planned this stud...

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Main Authors: Kanai Lal Barik, Projesh Biswas, Kuntal Kanti Das, Sumanta Laha, Sudipto Paul, Saikat Mondal
Format: Article
Language:English
Published: Manipal College of Medical Sciences, Pokhara 2022-01-01
Series:Asian Journal of Medical Sciences
Subjects:
Online Access:https://www.nepjol.info/index.php/AJMS/article/view/40014
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author Kanai Lal Barik
Projesh Biswas
Kuntal Kanti Das
Sumanta Laha
Sudipto Paul
Saikat Mondal
author_facet Kanai Lal Barik
Projesh Biswas
Kuntal Kanti Das
Sumanta Laha
Sudipto Paul
Saikat Mondal
author_sort Kanai Lal Barik
collection DOAJ
description Background: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. Aims and Objectives: We have planned this study to know the etiological agent of neonatal meningitis with its antibiotic sensitivity profile and to evaluate some other associated risk factors of meningitis. Materials and Methods: This observational, cross-sectional study was done for a period of 1 year in the SNCU and NICU of a district Medical College of West Bengal in neonates presented with clinical sepsis and meningitis. Sepsis screen, blood culture, cerebrospinal fluid (CSF) study, and culture sensitivity was done and recorded along with demographic data, clinical presentation, outcome, and other associated factors. Results: We found meningitis in 55 neonates out of 250 clinical sepsis. CSF culture was positive in 42 cases with Escherichia coli (30.9%), Klebsiella (26.1%), Staphylococcus aureus (16.6%), Acinetobacter (14.2%) and Coagulase negative Staphylococcus (CoNS 11.9%) as prevalent organism. E. coli and Klebsiella were mostly sensitive to Amikacin, Levofloxacin, and Colistin whereas less sensitive to Cefotaxime, Pipercilin-tazobactam or Meropenem and Acinetobacter showed good sensitivity only to Levofloxacin. Among the gram-positive organism, S. aureus and CoNS were only sensitive to Linezolid, Vancomycin, and Teicoplanin. Conclusion: This type of study should help to make a proper antibiotic policy for an institution so that the empirical first-line antibiotic can be started with good effect in cases of neonatal sepsis and meningitis before the arrival of culture sensitivity report.
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spelling doaj.art-07cd86f7e53c44018bf005e8cce77aed2022-12-21T21:21:28ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-01-011319398https://doi.org/10.3126/ajms.v13i1.40014Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West BengalKanai Lal Barik0https://orcid.org/0000-0001-8206-7783Projesh Biswas 1https://orcid.org/0000-0001-9826-372XKuntal Kanti Das 2https://orcid.org/0000-0003-3259-8222Sumanta Laha 3https://orcid.org/0000-0002-8215-4737Sudipto Paul 4https://orcid.org/0000-0003-4692-5845Saikat Mondal 5https://orcid.org/0000-0001-5387-4201Professor, Department of Pediatric Medicine, Burdwan Medical College, East Burdwan, West Bengal, India Senior Resident, Department of Pediatric Medicine, Burdwan Medical College, East Burdwan, West Bengal, India Tutor/Demonstrator, Department of Pediatric Medicine, Burdwan Medical College, East Burdwan, West Bengal, India Associate Professor, Department of Pediatric Medicine, Burdwan Medical College, East Burdwan, West Bengal, India Junior Resident, Department of Pediatric Medicine, Burdwan Medical College, East Burdwan, West Bengal, India Junior Resident, Department of Pediatric Medicine, Burdwan Medical College, East Burdwan, West Bengal, IndiaBackground: Neonatal sepsis and meningitis is an important cause of neonatal mortality and morbidity especially in the developing countries. Bacteriological profile of meningitis and antibiotic sensitivity pattern may vary from one region to another. Aims and Objectives: We have planned this study to know the etiological agent of neonatal meningitis with its antibiotic sensitivity profile and to evaluate some other associated risk factors of meningitis. Materials and Methods: This observational, cross-sectional study was done for a period of 1 year in the SNCU and NICU of a district Medical College of West Bengal in neonates presented with clinical sepsis and meningitis. Sepsis screen, blood culture, cerebrospinal fluid (CSF) study, and culture sensitivity was done and recorded along with demographic data, clinical presentation, outcome, and other associated factors. Results: We found meningitis in 55 neonates out of 250 clinical sepsis. CSF culture was positive in 42 cases with Escherichia coli (30.9%), Klebsiella (26.1%), Staphylococcus aureus (16.6%), Acinetobacter (14.2%) and Coagulase negative Staphylococcus (CoNS 11.9%) as prevalent organism. E. coli and Klebsiella were mostly sensitive to Amikacin, Levofloxacin, and Colistin whereas less sensitive to Cefotaxime, Pipercilin-tazobactam or Meropenem and Acinetobacter showed good sensitivity only to Levofloxacin. Among the gram-positive organism, S. aureus and CoNS were only sensitive to Linezolid, Vancomycin, and Teicoplanin. Conclusion: This type of study should help to make a proper antibiotic policy for an institution so that the empirical first-line antibiotic can be started with good effect in cases of neonatal sepsis and meningitis before the arrival of culture sensitivity report.https://www.nepjol.info/index.php/AJMS/article/view/40014antimicrobial susceptibilityetiologymeningitisneonates
spellingShingle Kanai Lal Barik
Projesh Biswas
Kuntal Kanti Das
Sumanta Laha
Sudipto Paul
Saikat Mondal
Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal
Asian Journal of Medical Sciences
antimicrobial susceptibility
etiology
meningitis
neonates
title Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal
title_full Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal
title_fullStr Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal
title_full_unstemmed Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal
title_short Bacteriological profile, antibiotic susceptibility pattern and other factors related to neonatal meningitis: A cross-sectional hospital-based study from West Bengal
title_sort bacteriological profile antibiotic susceptibility pattern and other factors related to neonatal meningitis a cross sectional hospital based study from west bengal
topic antimicrobial susceptibility
etiology
meningitis
neonates
url https://www.nepjol.info/index.php/AJMS/article/view/40014
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