Altered Functional Connectivity in Resting State Networks in Tourette’s Disorder
Introduction: Brain regions are anatomically and functionally interconnected in order to facilitate important functions like cognition and movement. It remains incompletely understood how brain connectivity contributes to the pathophysiology of Tourette’s disorder (TD). By using resting-state functi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2018.00363/full |
| _version_ | 1819153589469184000 |
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| author | Siyan Fan Siyan Fan Siyan Fan Odile A. van den Heuvel Odile A. van den Heuvel Odile A. van den Heuvel Danielle C. Cath Danielle C. Cath Stella J. de Wit Chris Vriend Chris Vriend Dick J. Veltman Ysbrand D. van der Werf |
| author_facet | Siyan Fan Siyan Fan Siyan Fan Odile A. van den Heuvel Odile A. van den Heuvel Odile A. van den Heuvel Danielle C. Cath Danielle C. Cath Stella J. de Wit Chris Vriend Chris Vriend Dick J. Veltman Ysbrand D. van der Werf |
| author_sort | Siyan Fan |
| collection | DOAJ |
| description | Introduction: Brain regions are anatomically and functionally interconnected in order to facilitate important functions like cognition and movement. It remains incompletely understood how brain connectivity contributes to the pathophysiology of Tourette’s disorder (TD). By using resting-state functional MRI, we aimed to identify alterations in the default mode network (DMN), frontal-parietal network (FPN), sensori-motor network (SMN), and salience network (SN) in TD compared with healthy control (HC) subjects.Method: In 23 adult TD patients and 22 HC, 3T-MRI resting-state scans were obtained. Independent component analysis was performed comparing TD and HC to investigate connectivity patterns within and between resting-state networks.Results: TD patients showed higher involvement of the dorsal medial prefrontal cortex in the connectivity of the DMN and less involvement of the inferior parietal cortex in the connectivity of the FPN when compared to HC. Moreover, TD patients showed a stronger coupling between DMN and left FPN than HC. Finally, in TD patients, functional connectivity within DMN correlated negatively with tic severity.Conclusion: We tentatively interpret the increased functional connectivity within DMN in TD patients as compensatory to the lower functional connectivity within left FPN. The stronger coupling between DMN and left FPN, together with the finding that higher DMN intrinsic connectivity is associated with lower tic severity would indicate that DMN is recruited to exert motor inhibition. |
| first_indexed | 2024-12-22T15:07:35Z |
| format | Article |
| id | doaj.art-07cda7ec43884f6cbbd2ebdf87ca9f2e |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T15:07:35Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-07cda7ec43884f6cbbd2ebdf87ca9f2e2022-12-21T18:21:57ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-09-011210.3389/fnhum.2018.00363351192Altered Functional Connectivity in Resting State Networks in Tourette’s DisorderSiyan Fan0Siyan Fan1Siyan Fan2Odile A. van den Heuvel3Odile A. van den Heuvel4Odile A. van den Heuvel5Danielle C. Cath6Danielle C. Cath7Stella J. de Wit8Chris Vriend9Chris Vriend10Dick J. Veltman11Ysbrand D. van der Werf12Division of Social and Behavioural Science, Utrecht University, Utrecht, NetherlandsDepartment of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsThe OCD Team, Haukeland University Hospital, Bergen, NorwayDivision of Social and Behavioural Science, Utrecht University, Utrecht, NetherlandsDepartment of Psychiatry and Rob Giel Research Center (RGOC), University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsIntroduction: Brain regions are anatomically and functionally interconnected in order to facilitate important functions like cognition and movement. It remains incompletely understood how brain connectivity contributes to the pathophysiology of Tourette’s disorder (TD). By using resting-state functional MRI, we aimed to identify alterations in the default mode network (DMN), frontal-parietal network (FPN), sensori-motor network (SMN), and salience network (SN) in TD compared with healthy control (HC) subjects.Method: In 23 adult TD patients and 22 HC, 3T-MRI resting-state scans were obtained. Independent component analysis was performed comparing TD and HC to investigate connectivity patterns within and between resting-state networks.Results: TD patients showed higher involvement of the dorsal medial prefrontal cortex in the connectivity of the DMN and less involvement of the inferior parietal cortex in the connectivity of the FPN when compared to HC. Moreover, TD patients showed a stronger coupling between DMN and left FPN than HC. Finally, in TD patients, functional connectivity within DMN correlated negatively with tic severity.Conclusion: We tentatively interpret the increased functional connectivity within DMN in TD patients as compensatory to the lower functional connectivity within left FPN. The stronger coupling between DMN and left FPN, together with the finding that higher DMN intrinsic connectivity is associated with lower tic severity would indicate that DMN is recruited to exert motor inhibition.https://www.frontiersin.org/article/10.3389/fnhum.2018.00363/fullresting-SsTourette Syndromefunctional connectivity (FC)default mode network (DMN)frontalparietal network |
| spellingShingle | Siyan Fan Siyan Fan Siyan Fan Odile A. van den Heuvel Odile A. van den Heuvel Odile A. van den Heuvel Danielle C. Cath Danielle C. Cath Stella J. de Wit Chris Vriend Chris Vriend Dick J. Veltman Ysbrand D. van der Werf Altered Functional Connectivity in Resting State Networks in Tourette’s Disorder Frontiers in Human Neuroscience resting-Ss Tourette Syndrome functional connectivity (FC) default mode network (DMN) frontalparietal network |
| title | Altered Functional Connectivity in Resting State Networks in Tourette’s Disorder |
| title_full | Altered Functional Connectivity in Resting State Networks in Tourette’s Disorder |
| title_fullStr | Altered Functional Connectivity in Resting State Networks in Tourette’s Disorder |
| title_full_unstemmed | Altered Functional Connectivity in Resting State Networks in Tourette’s Disorder |
| title_short | Altered Functional Connectivity in Resting State Networks in Tourette’s Disorder |
| title_sort | altered functional connectivity in resting state networks in tourette s disorder |
| topic | resting-Ss Tourette Syndrome functional connectivity (FC) default mode network (DMN) frontalparietal network |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2018.00363/full |
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