Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
Polyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total pol...
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3575 |
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| author | Chu-Yi Huang Yu-Jing Fang Alinuer Abulimiti Xia Yang Lei Li Kai-Yan Liu Xin Zhang Xiao-Li Feng Yu-Ming Chen Cai-Xia Zhang |
| author_facet | Chu-Yi Huang Yu-Jing Fang Alinuer Abulimiti Xia Yang Lei Li Kai-Yan Liu Xin Zhang Xiao-Li Feng Yu-Ming Chen Cai-Xia Zhang |
| author_sort | Chu-Yi Huang |
| collection | DOAJ |
| description | Polyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total polyamines, putrescine, spermidine, and spermine intake in relation to colorectal cancer risk in China. In total, 2502 colorectal cancer cases and 2538 age-(5-year interval) and sex-matched controls were recruited from July 2010 to April 2019. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by multivariable unconditional logistic regression after adjustment for various potential confounding factors. Higher intake of total polyamine, putrescine and spermidine was significantly associated with reduced risk of colorectal cancer. The adjusted ORs for the highest compared with the lowest quartile of intake were 0.60 (95% CI 0.50, 0.72; <i>P</i><sub>trend</sub> < 0.001) for total polyamines, 0.35 (95% CI 0.29, 0.43; <i>P</i><sub>trend</sub> < 0.001) for putrescine and 0.79 (95% CI 0.66, 0.95; <i>P</i><sub>trend</sub> = 0.001) for spermidine, respectively. However, higher intake of spermine was associated with increased risk of colorectal cancer, with an adjusted OR of 1.58 (95% CI 1.29, 1.93; <i>P</i><sub>trend</sub> < 0.001). This data indicate that higher intake of total polyamines, putrescine and spermidine, as well as lower intake of spermine, is associated with a decreased risk of colorectal cancer. |
| first_indexed | 2024-03-10T14:39:34Z |
| format | Article |
| id | doaj.art-07ce1483a2d34ac5aa62fac48f7f6a7a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:39:34Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-07ce1483a2d34ac5aa62fac48f7f6a7a2023-11-20T21:53:02ZengMDPI AGNutrients2072-66432020-11-011211357510.3390/nu12113575Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control StudyChu-Yi Huang0Yu-Jing Fang1Alinuer Abulimiti2Xia Yang3Lei Li4Kai-Yan Liu5Xin Zhang6Xiao-Li Feng7Yu-Ming Chen8Cai-Xia Zhang9Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Colorectal Surgery, Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Colorectal Surgery, Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaPolyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total polyamines, putrescine, spermidine, and spermine intake in relation to colorectal cancer risk in China. In total, 2502 colorectal cancer cases and 2538 age-(5-year interval) and sex-matched controls were recruited from July 2010 to April 2019. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by multivariable unconditional logistic regression after adjustment for various potential confounding factors. Higher intake of total polyamine, putrescine and spermidine was significantly associated with reduced risk of colorectal cancer. The adjusted ORs for the highest compared with the lowest quartile of intake were 0.60 (95% CI 0.50, 0.72; <i>P</i><sub>trend</sub> < 0.001) for total polyamines, 0.35 (95% CI 0.29, 0.43; <i>P</i><sub>trend</sub> < 0.001) for putrescine and 0.79 (95% CI 0.66, 0.95; <i>P</i><sub>trend</sub> = 0.001) for spermidine, respectively. However, higher intake of spermine was associated with increased risk of colorectal cancer, with an adjusted OR of 1.58 (95% CI 1.29, 1.93; <i>P</i><sub>trend</sub> < 0.001). This data indicate that higher intake of total polyamines, putrescine and spermidine, as well as lower intake of spermine, is associated with a decreased risk of colorectal cancer.https://www.mdpi.com/2072-6643/12/11/3575polyamineputrescinespermidinesperminecolorectal cancer |
| spellingShingle | Chu-Yi Huang Yu-Jing Fang Alinuer Abulimiti Xia Yang Lei Li Kai-Yan Liu Xin Zhang Xiao-Li Feng Yu-Ming Chen Cai-Xia Zhang Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study Nutrients polyamine putrescine spermidine spermine colorectal cancer |
| title | Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study |
| title_full | Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study |
| title_fullStr | Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study |
| title_full_unstemmed | Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study |
| title_short | Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study |
| title_sort | dietary polyamines intake and risk of colorectal cancer a case control study |
| topic | polyamine putrescine spermidine spermine colorectal cancer |
| url | https://www.mdpi.com/2072-6643/12/11/3575 |
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