Treatment of Darier’s disease with oral magnesium: a case report
Darier’s disease, an autosomal dominant genodermatosis, arises from a mutation in the ATP2A2 gene that codes for sarco/endoplasmic reticulum Ca 2+ -ATPase in the endoplasmic reticulum and is characterized by greasy keratotic papules commonly found in seborrheic regions. Conventional treatments, incl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-09-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X18795071 |
| _version_ | 1818941719663607808 |
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| author | Heidi Oi-Yee Li Sophia Colantonio Nordau Kanigsberg |
| author_facet | Heidi Oi-Yee Li Sophia Colantonio Nordau Kanigsberg |
| author_sort | Heidi Oi-Yee Li |
| collection | DOAJ |
| description | Darier’s disease, an autosomal dominant genodermatosis, arises from a mutation in the ATP2A2 gene that codes for sarco/endoplasmic reticulum Ca 2+ -ATPase in the endoplasmic reticulum and is characterized by greasy keratotic papules commonly found in seborrheic regions. Conventional treatments, including topical corticosteroids, antibiotics, antifungals and retinoids, often have limited efficacy. The present article reports the novel use of oral magnesium chloride supplementation (300 mg daily) in the treatment of Darier disease. After 5 years of limited improvement using conventional therapies, significant improvements in neck lesions were observed within 1 month of starting oral magnesium chloride. This suggests that oral magnesium chloride may be an effective therapeutic option for Darier disease, although further in vitro and clinical trials are necessary to evaluate its clinical efficacy. |
| first_indexed | 2024-12-20T07:00:01Z |
| format | Article |
| id | doaj.art-07d00e4e33d94f939ffa79a96e0a2698 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-20T07:00:01Z |
| publishDate | 2018-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-07d00e4e33d94f939ffa79a96e0a26982022-12-21T19:49:13ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2018-09-01610.1177/2050313X18795071Treatment of Darier’s disease with oral magnesium: a case reportHeidi Oi-Yee Li0Sophia Colantonio1Nordau Kanigsberg2University of Ottawa, Ottawa, ON, CanadaUniversity of Ottawa, Ottawa, ON, CanadaDivision of Dermatology, The Ottawa Hospital, Ottawa, ON, CanadaDarier’s disease, an autosomal dominant genodermatosis, arises from a mutation in the ATP2A2 gene that codes for sarco/endoplasmic reticulum Ca 2+ -ATPase in the endoplasmic reticulum and is characterized by greasy keratotic papules commonly found in seborrheic regions. Conventional treatments, including topical corticosteroids, antibiotics, antifungals and retinoids, often have limited efficacy. The present article reports the novel use of oral magnesium chloride supplementation (300 mg daily) in the treatment of Darier disease. After 5 years of limited improvement using conventional therapies, significant improvements in neck lesions were observed within 1 month of starting oral magnesium chloride. This suggests that oral magnesium chloride may be an effective therapeutic option for Darier disease, although further in vitro and clinical trials are necessary to evaluate its clinical efficacy.https://doi.org/10.1177/2050313X18795071 |
| spellingShingle | Heidi Oi-Yee Li Sophia Colantonio Nordau Kanigsberg Treatment of Darier’s disease with oral magnesium: a case report SAGE Open Medical Case Reports |
| title | Treatment of Darier’s disease with oral magnesium: a case report |
| title_full | Treatment of Darier’s disease with oral magnesium: a case report |
| title_fullStr | Treatment of Darier’s disease with oral magnesium: a case report |
| title_full_unstemmed | Treatment of Darier’s disease with oral magnesium: a case report |
| title_short | Treatment of Darier’s disease with oral magnesium: a case report |
| title_sort | treatment of darier s disease with oral magnesium a case report |
| url | https://doi.org/10.1177/2050313X18795071 |
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