Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study
ObjectivesPostpartum depression (PPD) is a severe postpartum psychiatric disorder with unclear pathogenesis. Previous neuroimaging studies have reported structural or functional alterations in areas associated with emotion regulation, cognitive disorder, and parenting behaviors of PPD. The primary g...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1138561/full |
| _version_ | 1797820210064916480 |
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| author | Chunlian Chen Bo Li Shufen Zhang Zhe Liu Yu Wang Minghe Xu Yuqing Ji Shuang Wang Gang Sun Kai Liu |
| author_facet | Chunlian Chen Bo Li Shufen Zhang Zhe Liu Yu Wang Minghe Xu Yuqing Ji Shuang Wang Gang Sun Kai Liu |
| author_sort | Chunlian Chen |
| collection | DOAJ |
| description | ObjectivesPostpartum depression (PPD) is a severe postpartum psychiatric disorder with unclear pathogenesis. Previous neuroimaging studies have reported structural or functional alterations in areas associated with emotion regulation, cognitive disorder, and parenting behaviors of PPD. The primary goal of this investigation was to explore the presence of brain structural alterations and relevant functional changes in PPD patients.MethodsA total of 28 patients and 30 matched healthy postnatal women (HPW) underwent both three-dimensional T1-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Structural analysis was performed by voxel-based morphometry (VBM), followed by resting-state functional analysis using a seed-based whole-brain functional connectivity (FC) approach with abnormal gray matter volume (GMV) regions as seed.ResultsCompared with HPW, the PPD patients showed increased GMV in the left dorsolateral prefrontal cortex (DLPFC.L), the right precentral gyrus (PrCG.R), and the orbitofrontal cortex (OFC). In the PPD group, the DLPFC.L showed increased FC with the right anterior cingulate and paracingulate gyri (ACG.R) and the right middle frontal gyrus (MFG.R); the FC between the PrCG.R and the right median cingulate and paracingulate gyri (DCG.R) exhibited enhanced; the OFC showed increased FC with MFG.R and the left inferior occipital gyrus (IOG.L). In PPD, GMV of DLPFC.L was positively correlated with EDPS scores (r = 0.409 p = 0.031), and FC of PrCG.R-DCG.R was positively correlated with EDPS scores (r = 0.483 p = 0.020).ConclusionStructural and functional damage of the DLPFC.L and OFC is associated with cognitive disorders and parenting behaviors in PPD, while structural abnormalities of the DLPFC.L and PrCG.R are involved in impaired executive function. The increased GMV of DLPFC.L may be a unique structural pathological mechanism of PPD related to the inability of PPD patients to withstand long-term parenting stress. These findings have important implications for understanding neural mechanisms in PPD. |
| first_indexed | 2024-03-13T09:35:03Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-13T09:35:03Z |
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| spelling | doaj.art-07d2055ae10d4ce4a62fabc14deb14d72023-05-25T14:31:28ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-05-011710.3389/fnins.2023.11385611138561Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity studyChunlian Chen0Bo Li1Shufen Zhang2Zhe Liu3Yu Wang4Minghe Xu5Yuqing Ji6Shuang Wang7Gang Sun8Kai Liu9Jinzhou Medical University, Jinzhou, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaDepartment of Obstetrics, Shandong Second Provincial General Hospital, Jinan, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaDepartment of Radiology, The 960th Hospital of the PLA Joint Logistic Support Force, Jinan, Shandong, ChinaObjectivesPostpartum depression (PPD) is a severe postpartum psychiatric disorder with unclear pathogenesis. Previous neuroimaging studies have reported structural or functional alterations in areas associated with emotion regulation, cognitive disorder, and parenting behaviors of PPD. The primary goal of this investigation was to explore the presence of brain structural alterations and relevant functional changes in PPD patients.MethodsA total of 28 patients and 30 matched healthy postnatal women (HPW) underwent both three-dimensional T1-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Structural analysis was performed by voxel-based morphometry (VBM), followed by resting-state functional analysis using a seed-based whole-brain functional connectivity (FC) approach with abnormal gray matter volume (GMV) regions as seed.ResultsCompared with HPW, the PPD patients showed increased GMV in the left dorsolateral prefrontal cortex (DLPFC.L), the right precentral gyrus (PrCG.R), and the orbitofrontal cortex (OFC). In the PPD group, the DLPFC.L showed increased FC with the right anterior cingulate and paracingulate gyri (ACG.R) and the right middle frontal gyrus (MFG.R); the FC between the PrCG.R and the right median cingulate and paracingulate gyri (DCG.R) exhibited enhanced; the OFC showed increased FC with MFG.R and the left inferior occipital gyrus (IOG.L). In PPD, GMV of DLPFC.L was positively correlated with EDPS scores (r = 0.409 p = 0.031), and FC of PrCG.R-DCG.R was positively correlated with EDPS scores (r = 0.483 p = 0.020).ConclusionStructural and functional damage of the DLPFC.L and OFC is associated with cognitive disorders and parenting behaviors in PPD, while structural abnormalities of the DLPFC.L and PrCG.R are involved in impaired executive function. The increased GMV of DLPFC.L may be a unique structural pathological mechanism of PPD related to the inability of PPD patients to withstand long-term parenting stress. These findings have important implications for understanding neural mechanisms in PPD.https://www.frontiersin.org/articles/10.3389/fnins.2023.1138561/fullpostpartum depressionfunctional connectivityvoxel-based morphometrystructural MRIResting-State fMRI |
| spellingShingle | Chunlian Chen Bo Li Shufen Zhang Zhe Liu Yu Wang Minghe Xu Yuqing Ji Shuang Wang Gang Sun Kai Liu Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study Frontiers in Neuroscience postpartum depression functional connectivity voxel-based morphometry structural MRI Resting-State fMRI |
| title | Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study |
| title_full | Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study |
| title_fullStr | Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study |
| title_full_unstemmed | Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study |
| title_short | Aberrant structural and functional alterations in postpartum depression: a combined voxel-based morphometry and resting-state functional connectivity study |
| title_sort | aberrant structural and functional alterations in postpartum depression a combined voxel based morphometry and resting state functional connectivity study |
| topic | postpartum depression functional connectivity voxel-based morphometry structural MRI Resting-State fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1138561/full |
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