Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer’s disease: three key timepoints through middle-age in females

Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer’s disease: three key timepoints through middle-age in females

Abstract The TgF344 rat model of Alzheimer’s disease (AD) provides a comprehensive neuropathology presentation, with age-dependent development of tau tangles, amyloid-beta (A $${\beta}$$ β ) plaques, neuronal loss, and increased gliosis. The behavioral trajectory of this model, particularly relating...

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Bibliographic Details
Main Authors: Victoria E. Bernaud, Haidyn L. Bulen, Veronica L. Peña, Stephanie V. Koebele, Steven N. Northup-Smith, Alma A. Manzo, Maria Valenzuela Sanchez, Zorana Opachich, Ashley M. Ruhland, Heather A. Bimonte-Nelson
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18415-1

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