Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process
RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/9/859 |
| _version_ | 1818312385117552640 |
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| author | Claire Muslin Alice Mac Kain Maël Bessaud Bruno Blondel Francis Delpeyroux |
| author_facet | Claire Muslin Alice Mac Kain Maël Bessaud Bruno Blondel Francis Delpeyroux |
| author_sort | Claire Muslin |
| collection | DOAJ |
| description | RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologous intertypic recombinant enteroviruses that were observed in nature would be the final products of a multi-step process, during which precursor nonhomologous recombinant genomes are generated through an initial inter-genomic RNA recombination event and can then evolve into a diversity of fitter homologous recombinant genomes over subsequent intra-genomic rearrangements. Moreover, these experimental studies demonstrated that the enterovirus genome could be defined as a combination of genomic modules that can be preferentially exchanged through recombination, and enabled defining the boundaries of these recombination modules. These results provided the first experimental evidence supporting the theoretical model of enterovirus modular evolution previously elaborated from phylogenetic studies of circulating enterovirus strains. This review summarizes our current knowledge regarding the mechanisms of recombination in enteroviruses and presents a new evolutionary process that may apply to other RNA viruses. |
| first_indexed | 2024-12-13T08:17:00Z |
| format | Article |
| id | doaj.art-07d71dd50a03480ebbedac39d98931b0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-13T08:17:00Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-07d71dd50a03480ebbedac39d98931b02022-12-21T23:54:05ZengMDPI AGViruses1999-49152019-09-0111985910.3390/v11090859v11090859Recombination in Enteroviruses, a Multi-Step Modular Evolutionary ProcessClaire Muslin0Alice Mac Kain1Maël Bessaud2Bruno Blondel3Francis Delpeyroux4One Health Research Group, Faculty of Health Sciences, Universidad de las Américas, Quito EC170125, Pichincha, EcuadorInstitut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, FranceInstitut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, FranceInstitut Pasteur, Biology of Enteric Viruses Unit, 75015 Paris, FranceInstitut Pasteur, Biology of Enteric Viruses Unit, 75015 Paris, FranceRNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologous intertypic recombinant enteroviruses that were observed in nature would be the final products of a multi-step process, during which precursor nonhomologous recombinant genomes are generated through an initial inter-genomic RNA recombination event and can then evolve into a diversity of fitter homologous recombinant genomes over subsequent intra-genomic rearrangements. Moreover, these experimental studies demonstrated that the enterovirus genome could be defined as a combination of genomic modules that can be preferentially exchanged through recombination, and enabled defining the boundaries of these recombination modules. These results provided the first experimental evidence supporting the theoretical model of enterovirus modular evolution previously elaborated from phylogenetic studies of circulating enterovirus strains. This review summarizes our current knowledge regarding the mechanisms of recombination in enteroviruses and presents a new evolutionary process that may apply to other RNA viruses.https://www.mdpi.com/1999-4915/11/9/859RNA virusrecombinationemergenceenterovirusviral evolution |
| spellingShingle | Claire Muslin Alice Mac Kain Maël Bessaud Bruno Blondel Francis Delpeyroux Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process Viruses RNA virus recombination emergence enterovirus viral evolution |
| title | Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process |
| title_full | Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process |
| title_fullStr | Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process |
| title_full_unstemmed | Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process |
| title_short | Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process |
| title_sort | recombination in enteroviruses a multi step modular evolutionary process |
| topic | RNA virus recombination emergence enterovirus viral evolution |
| url | https://www.mdpi.com/1999-4915/11/9/859 |
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