Design, synthesis and evaluation of novel tetrahydropyridothienopyrimidin-ureas as cytotoxic and anti-angiogenic agents

Design, synthesis and evaluation of novel tetrahydropyridothienopyrimidin-ureas as cytotoxic and anti-angiogenic agents

Abstract The novel derivatives of tetrahydropyridothienopyrimidine-based compounds have been designed and efficiently synthesized with good yields through seven steps reaction. The anticancer activity of compounds 11a-y has been evaluated against MCF-7, PC-3, HEPG-2, SW-480, and HUVEC cell lines by...

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Bibliographic Details
Main Authors:	Rasoul Motahari, Mohammad Amin Boshagh, Setareh Moghimi, Fariba Peytam, Zaman Hasanvand, Tayebeh Oghabi Bakhshaiesh, Roham Foroumadi, Hamidreza Bijanzadeh, Loghman Firoozpour, Ali Khalaj, Rezvan Esmaeili, Alireza Foroumadi
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-06-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-13515-4

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