Metabolic Reprogramming Promotes Myogenesis During Aging
Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during agin...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00897/full |
| _version_ | 1828392154690486272 |
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| author | Roberta Belli Agnese Bonato Luciana De Angelis Simone Mirabilii Maria Rosaria Ricciardi Agostino Tafuri Alessio Molfino Massimiliano Leigheb Paola Costelli Maurizia Caruso Maurizio Muscaritoli Elisabetta Ferraro Elisabetta Ferraro |
| author_facet | Roberta Belli Agnese Bonato Luciana De Angelis Simone Mirabilii Maria Rosaria Ricciardi Agostino Tafuri Alessio Molfino Massimiliano Leigheb Paola Costelli Maurizia Caruso Maurizio Muscaritoli Elisabetta Ferraro Elisabetta Ferraro |
| author_sort | Roberta Belli |
| collection | DOAJ |
| description | Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia. |
| first_indexed | 2024-12-10T07:15:14Z |
| format | Article |
| id | doaj.art-07d867eb6f3045bd8c494d1c8af7af2f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-10T07:15:14Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-07d867eb6f3045bd8c494d1c8af7af2f2022-12-22T01:57:56ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-07-011010.3389/fphys.2019.00897442450Metabolic Reprogramming Promotes Myogenesis During AgingRoberta Belli0Agnese Bonato1Luciana De Angelis2Simone Mirabilii3Maria Rosaria Ricciardi4Agostino Tafuri5Alessio Molfino6Massimiliano Leigheb7Paola Costelli8Maurizia Caruso9Maurizio Muscaritoli10Elisabetta Ferraro11Elisabetta Ferraro12Department of Translational and Precision Medicine (Formerly Department of Clinical Medicine), Sapienza University of Rome, Rome, ItalyInstitute of Cell Biology and Neurobiology, National Research Council (CNR), Rome, ItalySAIMLAL, Histology Department, Sapienza University of Rome, Rome, ItalyHematology, Sant’Andrea University Hospital, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, ItalyHematology, Sant’Andrea University Hospital, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, ItalyHematology, Sant’Andrea University Hospital, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Translational and Precision Medicine (Formerly Department of Clinical Medicine), Sapienza University of Rome, Rome, ItalyDepartment of Orthopaedics and Traumatology, Hospital “Maggiore della Carità”, Università del Piemonte Orientale (UPO), Novara, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyInstitute of Cell Biology and Neurobiology, National Research Council (CNR), Rome, ItalyDepartment of Translational and Precision Medicine (Formerly Department of Clinical Medicine), Sapienza University of Rome, Rome, ItalyDepartment of Orthopaedics and Traumatology, Hospital “Maggiore della Carità”, Università del Piemonte Orientale (UPO), Novara, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalySarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia.https://www.frontiersin.org/article/10.3389/fphys.2019.00897/fullmetabolic reprogrammingmyogenesistrimetazidinemitochondriaagingneuromuscular activity |
| spellingShingle | Roberta Belli Agnese Bonato Luciana De Angelis Simone Mirabilii Maria Rosaria Ricciardi Agostino Tafuri Alessio Molfino Massimiliano Leigheb Paola Costelli Maurizia Caruso Maurizio Muscaritoli Elisabetta Ferraro Elisabetta Ferraro Metabolic Reprogramming Promotes Myogenesis During Aging Frontiers in Physiology metabolic reprogramming myogenesis trimetazidine mitochondria aging neuromuscular activity |
| title | Metabolic Reprogramming Promotes Myogenesis During Aging |
| title_full | Metabolic Reprogramming Promotes Myogenesis During Aging |
| title_fullStr | Metabolic Reprogramming Promotes Myogenesis During Aging |
| title_full_unstemmed | Metabolic Reprogramming Promotes Myogenesis During Aging |
| title_short | Metabolic Reprogramming Promotes Myogenesis During Aging |
| title_sort | metabolic reprogramming promotes myogenesis during aging |
| topic | metabolic reprogramming myogenesis trimetazidine mitochondria aging neuromuscular activity |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00897/full |
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