Rationale and design of a multicenter, single-group, open-label trial aiming at investigating the effectiveness of elobixibat for loss of defecation desire in patients with chronic constipation

Rationale and design of a multicenter, single-group, open-label trial aiming at investigating the effectiveness of elobixibat for loss of defecation desire in patients with chronic constipation

Background: Approximately 60% of patients with chronic constipation (CC) have a significantly higher rate of loss of defecation desire (LODD). Bile acids are expected to have a restorative effect on defecation desire (DD) because they lower the rectal sensory threshold, which is an objective index o...

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Main Authors: Atsushi Yamamoto, Takaomi Kessoku, Kosuke Tanaka, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Tsutomu Yoshihara, Noboru Misawa, Kanji Ohkuma, Akiko Fuyuki, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Tomoyuki Iwasaki, Takeo Kurihashi, Machiko Nakatogawa, Ayao Suzuki, Masataka Taguri, Shunsuke Oyamada, Keisuke Ariyoshi, Noritoshi Kobayashi, Yasushi Ichikawa, Atsushi Nakajima
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Contemporary Clinical Trials Communications
Subjects:
Chronic constipation
Defecation desire
Elobixibat
Bile acid
Loss of defecation desire
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865422000758

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