Research progress on genetic mutation of congenital cataract
Cataract is a kind of eye disease that causes lens metabolic disorder and protein degeneration and turbidity due to various reasons. Congenital cataract is especially serious. It is a common eye disease that affects the visual development of infants. It can inhibit the development of visual pathway...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2020-02-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2020/2/202002013.pdf |
| _version_ | 1818317907788038144 |
|---|---|
| author | Ya-Nan Ji Juan-Mei Zhang You-Cai Zhao Jun Zhao Tao Jiang Dan Zhang Chun-Liu Tian Lin-Lin Zhang |
| author_facet | Ya-Nan Ji Juan-Mei Zhang You-Cai Zhao Jun Zhao Tao Jiang Dan Zhang Chun-Liu Tian Lin-Lin Zhang |
| author_sort | Ya-Nan Ji |
| collection | DOAJ |
| description | Cataract is a kind of eye disease that causes lens metabolic disorder and protein degeneration and turbidity due to various reasons. Congenital cataract is especially serious. It is a common eye disease that affects the visual development of infants. It can inhibit the development of visual pathway and cause permanent blindness. About one-third of the cases are genetically related, of which autosomal dominant inheritance is the most common genetic mode. It's occurrence and development may be related to genes involved in lens development. Up to now, hundreds of mutation sites in more than 40 genes have been found to be associated with congenital cataract. This article will review the genetic research progress of congenital cataract. |
| first_indexed | 2024-12-13T09:44:47Z |
| format | Article |
| id | doaj.art-07da975e02f743799cc32051e04865fe |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-13T09:44:47Z |
| publishDate | 2020-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-07da975e02f743799cc32051e04865fe2022-12-21T23:52:05ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232020-02-0120225525710.3980/j.issn.1672-5123.2020.2.13Research progress on genetic mutation of congenital cataractYa-Nan Ji0Juan-Mei Zhang1You-Cai Zhao2Jun Zhao3Tao Jiang4Dan Zhang5Chun-Liu Tian6Lin-Lin Zhang7Department of Medicine, Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, Linyi People's Hospital, Linyi 276000, Shandong Province, ChinaClinical College of Weifang Medical University, Weifang 261000, Shandong Province, ChinaDepartment of Ophthalmology, Linyi People's Hospital, Linyi 276000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Medicine, Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Medicine, Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Medicine, Qingdao University, Qingdao 266000, Shandong Province, ChinaCataract is a kind of eye disease that causes lens metabolic disorder and protein degeneration and turbidity due to various reasons. Congenital cataract is especially serious. It is a common eye disease that affects the visual development of infants. It can inhibit the development of visual pathway and cause permanent blindness. About one-third of the cases are genetically related, of which autosomal dominant inheritance is the most common genetic mode. It's occurrence and development may be related to genes involved in lens development. Up to now, hundreds of mutation sites in more than 40 genes have been found to be associated with congenital cataract. This article will review the genetic research progress of congenital cataract.http://ies.ijo.cn/cn_publish/2020/2/202002013.pdfcongenital cataracthereditygene mutationcrystallin genemembrane protein genetranscription regulator gene |
| spellingShingle | Ya-Nan Ji Juan-Mei Zhang You-Cai Zhao Jun Zhao Tao Jiang Dan Zhang Chun-Liu Tian Lin-Lin Zhang Research progress on genetic mutation of congenital cataract Guoji Yanke Zazhi congenital cataract heredity gene mutation crystallin gene membrane protein gene transcription regulator gene |
| title | Research progress on genetic mutation of congenital cataract |
| title_full | Research progress on genetic mutation of congenital cataract |
| title_fullStr | Research progress on genetic mutation of congenital cataract |
| title_full_unstemmed | Research progress on genetic mutation of congenital cataract |
| title_short | Research progress on genetic mutation of congenital cataract |
| title_sort | research progress on genetic mutation of congenital cataract |
| topic | congenital cataract heredity gene mutation crystallin gene membrane protein gene transcription regulator gene |
| url | http://ies.ijo.cn/cn_publish/2020/2/202002013.pdf |
| work_keys_str_mv | AT yananji researchprogressongeneticmutationofcongenitalcataract AT juanmeizhang researchprogressongeneticmutationofcongenitalcataract AT youcaizhao researchprogressongeneticmutationofcongenitalcataract AT junzhao researchprogressongeneticmutationofcongenitalcataract AT taojiang researchprogressongeneticmutationofcongenitalcataract AT danzhang researchprogressongeneticmutationofcongenitalcataract AT chunliutian researchprogressongeneticmutationofcongenitalcataract AT linlinzhang researchprogressongeneticmutationofcongenitalcataract |