Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss
Evidence indicates that inhalative anesthetics enhance the β-site amyloid precursor protein (APP)-cleaving enzyme (BACE) activity, increase amyloid beta 1-42 (Aβ<sub>1–42</sub>) aggregation, and modulate dendritic spine dynamics. However, the mechanisms of inhalative anesthetics on hippo...
Main Authors: | Xingxing Wang, Qinfang Shi, Arpit Kumar Pradhan, Laura Ziegon, Martin Schlegel, Gerhard Rammes |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/12/6637 |
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