Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss

Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss

Evidence indicates that inhalative anesthetics enhance the β-site amyloid precursor protein (APP)-cleaving enzyme (BACE) activity, increase amyloid beta 1-42 (Aβ<sub>1–42</sub>) aggregation, and modulate dendritic spine dynamics. However, the mechanisms of inhalative anesthetics on hippo...

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Bibliographic Details
Main Authors: Xingxing Wang, Qinfang Shi, Arpit Kumar Pradhan, Laura Ziegon, Martin Schlegel, Gerhard Rammes
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
isoflurane
sevoflurane
xenon
synaptic plasticity
β-site amyloid precursor protein-cleaving enzyme
dendritic spines
Online Access:https://www.mdpi.com/1422-0067/23/12/6637

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