Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series
Alzheimer disease (AD) is the most common cause of dementia worldwide. Its clinical manifestations include a progressive loss of memory and other cognitive domains, as well as brain atrophy. An elevated homocysteine level (>15 µmol/L), known as hyperhomocysteinemia, is also an attributing risk fa...
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| Format: | Article |
| Language: | English |
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Korea Geriatrics Society
2024-03-01
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| Series: | Annals of Geriatric Medicine and Research |
| Subjects: | |
| Online Access: | http://www.e-agmr.org/upload/pdf/agmr-23-0135.pdf |
| _version_ | 1827304376718327808 |
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| author | Ram Prakash Sah C. S. Vidya Pratibha Pereira Shubha Jayaram Anshu Kumar Yadav P. Sujatha |
| author_facet | Ram Prakash Sah C. S. Vidya Pratibha Pereira Shubha Jayaram Anshu Kumar Yadav P. Sujatha |
| author_sort | Ram Prakash Sah |
| collection | DOAJ |
| description | Alzheimer disease (AD) is the most common cause of dementia worldwide. Its clinical manifestations include a progressive loss of memory and other cognitive domains, as well as brain atrophy. An elevated homocysteine level (>15 µmol/L), known as hyperhomocysteinemia, is also an attributing risk factor for AD, vascular pathologies, and brain atrophy. Neuroimaging studies including T2-weighted magnetic resonance imaging scans revealed white matter hyperintensities in the periventricular and deep white matter, enlarged ventricles, widened sulci, and decreased white matter mass, which are features of aging, as well as cerebrovascular changes. This case series investigated changes in biochemical marker levels including serum homocysteine, folate, and vitamin B12, and the degree of atrophic variations in cortical-subcortical white matter in AD. The present study hypothesized that serum homocysteine levels might be used as a surrogate marker to screen for AD at an earlier stage. |
| first_indexed | 2024-04-24T17:30:03Z |
| format | Article |
| id | doaj.art-07db3dff604c45fc97573b5101d3670c |
| institution | Directory Open Access Journal |
| issn | 2508-4798 2508-4909 |
| language | English |
| last_indexed | 2024-04-24T17:30:03Z |
| publishDate | 2024-03-01 |
| publisher | Korea Geriatrics Society |
| record_format | Article |
| series | Annals of Geriatric Medicine and Research |
| spelling | doaj.art-07db3dff604c45fc97573b5101d3670c2024-03-28T06:32:19ZengKorea Geriatrics SocietyAnnals of Geriatric Medicine and Research2508-47982508-49092024-03-0128111612010.4235/agmr.23.01351104Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case SeriesRam Prakash Sah0C. S. Vidya1Pratibha Pereira2Shubha Jayaram3Anshu Kumar Yadav4P. Sujatha5 Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India Department of Geriatric Medicine, JSS Hospital, JSS Academy of Higher Education and Research, Mysore, India Department of Biochemistry, Mysore Medical College and Research Institute, Mysore, India Department of Biochemistry and Medical Genetics, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, IndiaAlzheimer disease (AD) is the most common cause of dementia worldwide. Its clinical manifestations include a progressive loss of memory and other cognitive domains, as well as brain atrophy. An elevated homocysteine level (>15 µmol/L), known as hyperhomocysteinemia, is also an attributing risk factor for AD, vascular pathologies, and brain atrophy. Neuroimaging studies including T2-weighted magnetic resonance imaging scans revealed white matter hyperintensities in the periventricular and deep white matter, enlarged ventricles, widened sulci, and decreased white matter mass, which are features of aging, as well as cerebrovascular changes. This case series investigated changes in biochemical marker levels including serum homocysteine, folate, and vitamin B12, and the degree of atrophic variations in cortical-subcortical white matter in AD. The present study hypothesized that serum homocysteine levels might be used as a surrogate marker to screen for AD at an earlier stage.http://www.e-agmr.org/upload/pdf/agmr-23-0135.pdfalzheimer's diseasebrain atrophyhomocysteinevitamin b12 |
| spellingShingle | Ram Prakash Sah C. S. Vidya Pratibha Pereira Shubha Jayaram Anshu Kumar Yadav P. Sujatha Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series Annals of Geriatric Medicine and Research alzheimer's disease brain atrophy homocysteine vitamin b12 |
| title | Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series |
| title_full | Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series |
| title_fullStr | Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series |
| title_full_unstemmed | Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series |
| title_short | Elevated Homocysteine Level and Brain Atrophy Changes as Markers to Screen the Alzheimer Disease: Case Series |
| title_sort | elevated homocysteine level and brain atrophy changes as markers to screen the alzheimer disease case series |
| topic | alzheimer's disease brain atrophy homocysteine vitamin b12 |
| url | http://www.e-agmr.org/upload/pdf/agmr-23-0135.pdf |
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