Study of the relationship between serum lipid levels and primary open-angle glaucoma
Purpose: To determine the association between serum lipid levels and primary open-angle glaucoma (POAG). Methods: In this case-control study, 50 patients with POAG documented by clinical tests using standard ophthalmologic equipment and 50 age-matched controls were investigated. Twelve-hour fastin...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=1948;epage=1952;aulast=Joshi |
| _version_ | 1797775127080861696 |
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| author | Rajesh Subhash Joshi Vaishnavi Hitesh Adatiya |
| author_facet | Rajesh Subhash Joshi Vaishnavi Hitesh Adatiya |
| author_sort | Rajesh Subhash Joshi |
| collection | DOAJ |
| description | Purpose: To determine the association between serum lipid levels and primary open-angle glaucoma (POAG). Methods: In this case-control study, 50 patients with POAG documented by clinical tests using standard ophthalmologic equipment and 50 age-matched controls were investigated. Twelve-hour fasting serum lipid profiles, including total cholesterol, serum triglycerides, low-density lipoproteins (LDLs), and high-density lipoproteins (HDLs), were compared between the cases and controls. Results: The mean age of cases and controls was 62.84 ± 9.68 and 60.12 ± 8.65, respectively (P = 0.65). High total cholesterol levels (>200 mg/dl) were found in 23 cases (46%) and 8 controls (16%); high serum triglyceride levels (>150 mg/dl) were found in 24 cases (48%) and 7 controls (14%); high LDL levels (130 mg/dl) were found in 28 cases (56%) and 9 controls (18%); and low HDL levels (<40 mg/dl) were found in 38 cases (76%) and 30 controls (60%). The mean total cholesterol levels were 205.24 ± 36.90 mg/dl in cases and 177.68 ± 22.56 mg/dl in controls (P < 0.001); the mean serum triglyceride levels were 150.42 ± 49.55 mg/dl and 130.84 ± 23.16 mg/dl, respectively (P = 0.013); and the mean LDL levels were 139.50 ± 31.03 mg/dl and 114.96 ± 17.73 mg/dl, respectively (P < 0.001). The mean cholesterol, triglyceride, and LDL levels were significantly higher in cases than in controls (P < 0.05). Conclusion: The present study shows that higher proportion of POAG patients have dyslipidemia compared to age-matched controls. Though these findings need to be replicated by others. This study opens new vistas for further studies, such as lowering dyslipidemia, lowering the intra-ocular pressure and incidence of POAG, and whether the use of statins to reduce dyslipidemia affects the progression of POAG. |
| first_indexed | 2024-03-12T22:31:12Z |
| format | Article |
| id | doaj.art-07db92c5377a4b0abfaf762bc8293831 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-03-12T22:31:12Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-07db92c5377a4b0abfaf762bc82938312023-07-21T15:14:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892023-01-017151948195210.4103/IJO.IJO_3233_22Study of the relationship between serum lipid levels and primary open-angle glaucomaRajesh Subhash JoshiVaishnavi Hitesh AdatiyaPurpose: To determine the association between serum lipid levels and primary open-angle glaucoma (POAG). Methods: In this case-control study, 50 patients with POAG documented by clinical tests using standard ophthalmologic equipment and 50 age-matched controls were investigated. Twelve-hour fasting serum lipid profiles, including total cholesterol, serum triglycerides, low-density lipoproteins (LDLs), and high-density lipoproteins (HDLs), were compared between the cases and controls. Results: The mean age of cases and controls was 62.84 ± 9.68 and 60.12 ± 8.65, respectively (P = 0.65). High total cholesterol levels (>200 mg/dl) were found in 23 cases (46%) and 8 controls (16%); high serum triglyceride levels (>150 mg/dl) were found in 24 cases (48%) and 7 controls (14%); high LDL levels (130 mg/dl) were found in 28 cases (56%) and 9 controls (18%); and low HDL levels (<40 mg/dl) were found in 38 cases (76%) and 30 controls (60%). The mean total cholesterol levels were 205.24 ± 36.90 mg/dl in cases and 177.68 ± 22.56 mg/dl in controls (P < 0.001); the mean serum triglyceride levels were 150.42 ± 49.55 mg/dl and 130.84 ± 23.16 mg/dl, respectively (P = 0.013); and the mean LDL levels were 139.50 ± 31.03 mg/dl and 114.96 ± 17.73 mg/dl, respectively (P < 0.001). The mean cholesterol, triglyceride, and LDL levels were significantly higher in cases than in controls (P < 0.05). Conclusion: The present study shows that higher proportion of POAG patients have dyslipidemia compared to age-matched controls. Though these findings need to be replicated by others. This study opens new vistas for further studies, such as lowering dyslipidemia, lowering the intra-ocular pressure and incidence of POAG, and whether the use of statins to reduce dyslipidemia affects the progression of POAG.http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=1948;epage=1952;aulast=Joshidyslipidemiaprimary open-angle glaucomaserum lipid levelsserum total cholesterolserum triglycerides |
| spellingShingle | Rajesh Subhash Joshi Vaishnavi Hitesh Adatiya Study of the relationship between serum lipid levels and primary open-angle glaucoma Indian Journal of Ophthalmology dyslipidemia primary open-angle glaucoma serum lipid levels serum total cholesterol serum triglycerides |
| title | Study of the relationship between serum lipid levels and primary open-angle glaucoma |
| title_full | Study of the relationship between serum lipid levels and primary open-angle glaucoma |
| title_fullStr | Study of the relationship between serum lipid levels and primary open-angle glaucoma |
| title_full_unstemmed | Study of the relationship between serum lipid levels and primary open-angle glaucoma |
| title_short | Study of the relationship between serum lipid levels and primary open-angle glaucoma |
| title_sort | study of the relationship between serum lipid levels and primary open angle glaucoma |
| topic | dyslipidemia primary open-angle glaucoma serum lipid levels serum total cholesterol serum triglycerides |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=1948;epage=1952;aulast=Joshi |
| work_keys_str_mv | AT rajeshsubhashjoshi studyoftherelationshipbetweenserumlipidlevelsandprimaryopenangleglaucoma AT vaishnavihiteshadatiya studyoftherelationshipbetweenserumlipidlevelsandprimaryopenangleglaucoma |