The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trial
Objectives: This study aimed to assess the effects of Liothyronine supplementation on memory performance in patients diagnosed with mood disorders (major depressive or bipolar disorder).Methods: This double-blind controlled clinical trial was conducted on patients with major depression and bipolar d...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kashan University of Medical Sciences
2024-02-01
|
| Series: | International Archives of Health Sciences |
| Subjects: | |
| Online Access: | http://iahsj.kaums.ac.ir/article_187493_578b94b74c063726fb986cd3ffb9aea0.pdf |
| _version_ | 1827291953578901504 |
|---|---|
| author | Pooya Hazegh Fatemeh Sadat Ghoreishi Fatemeh Assarian Amir Ghaderi |
| author_facet | Pooya Hazegh Fatemeh Sadat Ghoreishi Fatemeh Assarian Amir Ghaderi |
| author_sort | Pooya Hazegh |
| collection | DOAJ |
| description | Objectives: This study aimed to assess the effects of Liothyronine supplementation on memory performance in patients diagnosed with mood disorders (major depressive or bipolar disorder).Methods: This double-blind controlled clinical trial was conducted on patients with major depression and bipolar disorder. The participants were randomly assigned to either the intervention group receiving Liothyronine or the placebo group, with 33 patients in each group, for a duration of one month. Memory performance was assessed before the first, fourth, and final ECT sessions, as well as one month after the last session using the Wechsler Memory Scale-Revised (WMS-R). Data analysis was performed using independent-samples Chi-square test and the Greenhouse-Geisser correction factor.Results: Liothyronine significantly enhanced communicative learning and visual memory in patients with major depression and bipolar disorder one month after the final ECT session. Additionally, a positive effect of Liothyronine on immediate recall was observed before the last ECT session.Conclusion: Liothyronine supplementation improves ECT-induced cognitive impairment in patients with major depression and bipolar disorder. Further research is necessary to fully comprehend the potential of Liothyronine as an adjunctive treatment for major depression and bipolar disorder. |
| first_indexed | 2024-04-24T12:47:28Z |
| format | Article |
| id | doaj.art-07dc15a1576445bdb47e4ca88001655e |
| institution | Directory Open Access Journal |
| issn | 2383-2568 |
| language | English |
| last_indexed | 2024-04-24T12:47:28Z |
| publishDate | 2024-02-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | International Archives of Health Sciences |
| spelling | doaj.art-07dc15a1576445bdb47e4ca88001655e2024-04-06T16:39:10ZengKashan University of Medical SciencesInternational Archives of Health Sciences2383-25682024-02-01111495510.48307/iahsj.2023.407118.1011187493The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trialPooya Hazegh0Fatemeh Sadat Ghoreishi1Fatemeh Assarian2Amir Ghaderi3Department of Psychiatry, School of Medicine, Kashan University of Medical Science, Kashan, IranDepartment of Psychiatry, School of Medicine, Kashan University of Medical Science, Kashan, IranDepartment of Psychiatry, School of Medicine, Kashan University of Medical Science, Kashan, IranDepartment of Addiction Studies, School of Medicine AND Clinical Research Development Unit, Matini/Kargarnejad Hospital, Kashan University of Medical Sciences, Kashan, IranObjectives: This study aimed to assess the effects of Liothyronine supplementation on memory performance in patients diagnosed with mood disorders (major depressive or bipolar disorder).Methods: This double-blind controlled clinical trial was conducted on patients with major depression and bipolar disorder. The participants were randomly assigned to either the intervention group receiving Liothyronine or the placebo group, with 33 patients in each group, for a duration of one month. Memory performance was assessed before the first, fourth, and final ECT sessions, as well as one month after the last session using the Wechsler Memory Scale-Revised (WMS-R). Data analysis was performed using independent-samples Chi-square test and the Greenhouse-Geisser correction factor.Results: Liothyronine significantly enhanced communicative learning and visual memory in patients with major depression and bipolar disorder one month after the final ECT session. Additionally, a positive effect of Liothyronine on immediate recall was observed before the last ECT session.Conclusion: Liothyronine supplementation improves ECT-induced cognitive impairment in patients with major depression and bipolar disorder. Further research is necessary to fully comprehend the potential of Liothyronine as an adjunctive treatment for major depression and bipolar disorder.http://iahsj.kaums.ac.ir/article_187493_578b94b74c063726fb986cd3ffb9aea0.pdfliothyronineelectroconvulsive therapymemorydepressive disorderbipolar disorder |
| spellingShingle | Pooya Hazegh Fatemeh Sadat Ghoreishi Fatemeh Assarian Amir Ghaderi The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trial International Archives of Health Sciences liothyronine electroconvulsive therapy memory depressive disorder bipolar disorder |
| title | The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trial |
| title_full | The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trial |
| title_fullStr | The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trial |
| title_full_unstemmed | The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trial |
| title_short | The effect of liothyronine supplementation on electroconvulsive therapy-induced cognitive impairment in patients with mood disorders: a clinical trial |
| title_sort | effect of liothyronine supplementation on electroconvulsive therapy induced cognitive impairment in patients with mood disorders a clinical trial |
| topic | liothyronine electroconvulsive therapy memory depressive disorder bipolar disorder |
| url | http://iahsj.kaums.ac.ir/article_187493_578b94b74c063726fb986cd3ffb9aea0.pdf |
| work_keys_str_mv | AT pooyahazegh theeffectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial AT fatemehsadatghoreishi theeffectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial AT fatemehassarian theeffectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial AT amirghaderi theeffectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial AT pooyahazegh effectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial AT fatemehsadatghoreishi effectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial AT fatemehassarian effectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial AT amirghaderi effectofliothyroninesupplementationonelectroconvulsivetherapyinducedcognitiveimpairmentinpatientswithmooddisordersaclinicaltrial |