Low muscle mass and mortality risk later in life: A 10-year follow-up study.
<h4>Introduction</h4>Little is known about the impact of low muscle mass (MM) assessed by calf circumference (CC), arm circumference (AC), arm muscle circumference (AMC), and corrected arm muscle circumference (CAMC)-on mortality risk later in life. We aimed to investigate the impact of...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0271579 |
| _version_ | 1811214698339631104 |
|---|---|
| author | Cristina Camargo Pereira Valéria Pagotto Cesar de Oliveira Erika Aparecida Silveira |
| author_facet | Cristina Camargo Pereira Valéria Pagotto Cesar de Oliveira Erika Aparecida Silveira |
| author_sort | Cristina Camargo Pereira |
| collection | DOAJ |
| description | <h4>Introduction</h4>Little is known about the impact of low muscle mass (MM) assessed by calf circumference (CC), arm circumference (AC), arm muscle circumference (AMC), and corrected arm muscle circumference (CAMC)-on mortality risk later in life. We aimed to investigate the impact of low MM assessed by CC, AC, AMC and, CAMC on all-cause, cardiovascular, and cancer mortality risk.<h4>Methods</h4>Data came from 418 older adults who participated in a 10-year follow-up prospective cohort study. Low MM was defined as a CC < 33 cm for women and < 34 cm for men and by the lowest tertile of AC, AMC, and CAMC stratified by sex. The log rank test, Kaplan-Meier curves, and Cox regression were used.<h4>Results</h4>There were 147 deaths: 49 related to CVD and 22 to cancer. A small CC (HR = 1.57, 95% CI, 1.12-2.20), AMC (HR = 1.61, 95% CI, 1.13-2.30) and CAMC (HR = 1.45, 95% CI, 1.03-2.04) were associated with all-cause mortality. A small CAMC was a protective factor for CVD mortality (HR = 0.46, 95% CI, 0.22-0.98). In the Kaplan-Meier analysis, older adults with LMM presented low all-cause mortality survival, with AC (p < 0.05), AMC (p < 0.005), CAMC (p < 0.002), and CC (p < 0.001). Cancer mortality was associated with low CAMC (p < 0.020).<h4>Conclusions</h4>Low MM assessed by anthropometric measures (AC, AMC, CAMC and CC) increased the all-cause mortality risk. A small CAMC decreased the CVD mortality. |
| first_indexed | 2024-04-12T06:09:03Z |
| format | Article |
| id | doaj.art-07dc22c6002248f0ab4dada48ba753c5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T06:09:03Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-07dc22c6002248f0ab4dada48ba753c52022-12-22T03:44:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01177e027157910.1371/journal.pone.0271579Low muscle mass and mortality risk later in life: A 10-year follow-up study.Cristina Camargo PereiraValéria PagottoCesar de OliveiraErika Aparecida Silveira<h4>Introduction</h4>Little is known about the impact of low muscle mass (MM) assessed by calf circumference (CC), arm circumference (AC), arm muscle circumference (AMC), and corrected arm muscle circumference (CAMC)-on mortality risk later in life. We aimed to investigate the impact of low MM assessed by CC, AC, AMC and, CAMC on all-cause, cardiovascular, and cancer mortality risk.<h4>Methods</h4>Data came from 418 older adults who participated in a 10-year follow-up prospective cohort study. Low MM was defined as a CC < 33 cm for women and < 34 cm for men and by the lowest tertile of AC, AMC, and CAMC stratified by sex. The log rank test, Kaplan-Meier curves, and Cox regression were used.<h4>Results</h4>There were 147 deaths: 49 related to CVD and 22 to cancer. A small CC (HR = 1.57, 95% CI, 1.12-2.20), AMC (HR = 1.61, 95% CI, 1.13-2.30) and CAMC (HR = 1.45, 95% CI, 1.03-2.04) were associated with all-cause mortality. A small CAMC was a protective factor for CVD mortality (HR = 0.46, 95% CI, 0.22-0.98). In the Kaplan-Meier analysis, older adults with LMM presented low all-cause mortality survival, with AC (p < 0.05), AMC (p < 0.005), CAMC (p < 0.002), and CC (p < 0.001). Cancer mortality was associated with low CAMC (p < 0.020).<h4>Conclusions</h4>Low MM assessed by anthropometric measures (AC, AMC, CAMC and CC) increased the all-cause mortality risk. A small CAMC decreased the CVD mortality.https://doi.org/10.1371/journal.pone.0271579 |
| spellingShingle | Cristina Camargo Pereira Valéria Pagotto Cesar de Oliveira Erika Aparecida Silveira Low muscle mass and mortality risk later in life: A 10-year follow-up study. PLoS ONE |
| title | Low muscle mass and mortality risk later in life: A 10-year follow-up study. |
| title_full | Low muscle mass and mortality risk later in life: A 10-year follow-up study. |
| title_fullStr | Low muscle mass and mortality risk later in life: A 10-year follow-up study. |
| title_full_unstemmed | Low muscle mass and mortality risk later in life: A 10-year follow-up study. |
| title_short | Low muscle mass and mortality risk later in life: A 10-year follow-up study. |
| title_sort | low muscle mass and mortality risk later in life a 10 year follow up study |
| url | https://doi.org/10.1371/journal.pone.0271579 |
| work_keys_str_mv | AT cristinacamargopereira lowmusclemassandmortalityrisklaterinlifea10yearfollowupstudy AT valeriapagotto lowmusclemassandmortalityrisklaterinlifea10yearfollowupstudy AT cesardeoliveira lowmusclemassandmortalityrisklaterinlifea10yearfollowupstudy AT erikaaparecidasilveira lowmusclemassandmortalityrisklaterinlifea10yearfollowupstudy |