Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study
IntroductionThe purpose of this study was to examine whether blood-based biomarkers associate with neurobehavioral functioning at three time points following traumatic brain injury (TBI).Materials and methodsParticipants were 328 United States service members and veterans (SMVs) prospectively enroll...
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Frontiers Media S.A.
2024-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1223960/full |
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| author | Katie A. Edwards Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Sara M. Lippa Sara M. Lippa Sara M. Lippa Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Jessica M. Gill Louis M. French Louis M. French Louis M. French Louis M. French |
| author_facet | Katie A. Edwards Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Sara M. Lippa Sara M. Lippa Sara M. Lippa Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Jessica M. Gill Louis M. French Louis M. French Louis M. French Louis M. French |
| author_sort | Katie A. Edwards |
| collection | DOAJ |
| description | IntroductionThe purpose of this study was to examine whether blood-based biomarkers associate with neurobehavioral functioning at three time points following traumatic brain injury (TBI).Materials and methodsParticipants were 328 United States service members and veterans (SMVs) prospectively enrolled in the Defense and Veterans Brain Injury Center-Traumatic Brain Injury Center of Excellence (DVBIC-TBICoE) 15-Year Longitudinal TBI Study, recruited into three groups: uncomplicated mild TBI (MTBI, n = 155); complicated mild, moderate, severe TBI combined (STBI, n = 97); non-injured controls (NIC, n = 76). Participants were further divided into three cohorts based on time since injury (≤12 months, 3–5 years, and 8–10 years). Participants completed the Minnesota Multiphasic Personality Inventory-2-Restructured Format (MMPI-2-RF) and underwent blood draw to measure serum concentrations of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and tau. A total of 11 MMPI-2-RF scales were examined (e.g., depression, anxiety, anger, somatic, cognitive symptoms). Stepwise hierarchical regression models were conducted within each group.ResultsSignificant associations were found between biomarkers and MMPI-2-RF scales (all p < 0.05; R2Δ > 0.10). GFAP was inversely related to (a) neurological complaints in the MTBI group at ≤12 months, (b) demoralization, anger proneness in the STBI group at ≤12 months, and (c) head pain complaints in the STBI group at 8–10 years. NfL was (a) related to low positive emotions in the NIC group; and inversely related to (b) demoralization, somatic complaints, neurological complaints, cognitive complaints in the MTBI group at ≤12 months, (c) demoralization in the STBI group at ≤12 months, and (d) demoralization, head pain complaints, stress/worry in the STBI group at 3–5 years. In the STBI group, there were meaningful findings (R2Δ > 0.10) for tau, NFL, and GFAP that did not reach statistical significance.DiscussionResults indicate worse scores on some MMPI-2-RF scales (e.g., depression, stress/worry, neurological and head pain complaints) were associated with lower concentrations of serum GFAP, NfL, and tau in the sub-acute and chronic phase of the recovery trajectory up to 5 years post-injury, with a reverse trend observed at 8–10 years. Longitudinal studies are needed to help elucidate any patterns of association between blood-based biomarkers and neurobehavioral outcome over the recovery trajectory following TBI. |
| first_indexed | 2024-03-08T13:37:56Z |
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| language | English |
| last_indexed | 2024-03-08T13:37:56Z |
| publishDate | 2024-01-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-07de66eca88f477281ecd1188af30fd22024-01-16T13:05:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-01-011410.3389/fneur.2023.12239601223960Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort studyKatie A. Edwards0Rael T. Lange1Rael T. Lange2Rael T. Lange3Rael T. Lange4Rael T. Lange5Rael T. Lange6Sara M. Lippa7Sara M. Lippa8Sara M. Lippa9Tracey A. Brickell10Tracey A. Brickell11Tracey A. Brickell12Tracey A. Brickell13Tracey A. Brickell14Jessica M. Gill15Louis M. French16Louis M. French17Louis M. French18Louis M. French19School of Nursing, Johns Hopkins University, Baltimore, MD, United StatesTraumatic Brain Injury Center of Excellence, Silver Spring, MD, United StatesWalter Reed National Military Medical Center, Bethesda, MD, United StatesNational Intrepid Center of Excellence, Bethesda, MD, United StatesGeneral Dynamics Information Technology, Silver Spring, MD, United StatesDepartment of Psychiatry, University of British Columbia, Vancouver, BC, CanadaDepartment of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesWalter Reed National Military Medical Center, Bethesda, MD, United StatesNational Intrepid Center of Excellence, Bethesda, MD, United StatesDepartment of Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesTraumatic Brain Injury Center of Excellence, Silver Spring, MD, United StatesWalter Reed National Military Medical Center, Bethesda, MD, United StatesNational Intrepid Center of Excellence, Bethesda, MD, United StatesGeneral Dynamics Information Technology, Silver Spring, MD, United StatesDepartment of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesSchool of Nursing, Johns Hopkins University, Baltimore, MD, United StatesTraumatic Brain Injury Center of Excellence, Silver Spring, MD, United StatesWalter Reed National Military Medical Center, Bethesda, MD, United StatesNational Intrepid Center of Excellence, Bethesda, MD, United StatesDepartment of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesIntroductionThe purpose of this study was to examine whether blood-based biomarkers associate with neurobehavioral functioning at three time points following traumatic brain injury (TBI).Materials and methodsParticipants were 328 United States service members and veterans (SMVs) prospectively enrolled in the Defense and Veterans Brain Injury Center-Traumatic Brain Injury Center of Excellence (DVBIC-TBICoE) 15-Year Longitudinal TBI Study, recruited into three groups: uncomplicated mild TBI (MTBI, n = 155); complicated mild, moderate, severe TBI combined (STBI, n = 97); non-injured controls (NIC, n = 76). Participants were further divided into three cohorts based on time since injury (≤12 months, 3–5 years, and 8–10 years). Participants completed the Minnesota Multiphasic Personality Inventory-2-Restructured Format (MMPI-2-RF) and underwent blood draw to measure serum concentrations of glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and tau. A total of 11 MMPI-2-RF scales were examined (e.g., depression, anxiety, anger, somatic, cognitive symptoms). Stepwise hierarchical regression models were conducted within each group.ResultsSignificant associations were found between biomarkers and MMPI-2-RF scales (all p < 0.05; R2Δ > 0.10). GFAP was inversely related to (a) neurological complaints in the MTBI group at ≤12 months, (b) demoralization, anger proneness in the STBI group at ≤12 months, and (c) head pain complaints in the STBI group at 8–10 years. NfL was (a) related to low positive emotions in the NIC group; and inversely related to (b) demoralization, somatic complaints, neurological complaints, cognitive complaints in the MTBI group at ≤12 months, (c) demoralization in the STBI group at ≤12 months, and (d) demoralization, head pain complaints, stress/worry in the STBI group at 3–5 years. In the STBI group, there were meaningful findings (R2Δ > 0.10) for tau, NFL, and GFAP that did not reach statistical significance.DiscussionResults indicate worse scores on some MMPI-2-RF scales (e.g., depression, stress/worry, neurological and head pain complaints) were associated with lower concentrations of serum GFAP, NfL, and tau in the sub-acute and chronic phase of the recovery trajectory up to 5 years post-injury, with a reverse trend observed at 8–10 years. Longitudinal studies are needed to help elucidate any patterns of association between blood-based biomarkers and neurobehavioral outcome over the recovery trajectory following TBI.https://www.frontiersin.org/articles/10.3389/fneur.2023.1223960/fulltraumatic brain injurytauglial fibrillary acidic protein (GFAP)neurofilament light (NfL)militaryneurobehavior |
| spellingShingle | Katie A. Edwards Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Rael T. Lange Sara M. Lippa Sara M. Lippa Sara M. Lippa Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Tracey A. Brickell Jessica M. Gill Louis M. French Louis M. French Louis M. French Louis M. French Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study Frontiers in Neurology traumatic brain injury tau glial fibrillary acidic protein (GFAP) neurofilament light (NfL) military neurobehavior |
| title | Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study |
| title_full | Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study |
| title_fullStr | Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study |
| title_full_unstemmed | Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study |
| title_short | Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study |
| title_sort | serum gfap nfl and tau concentrations are associated with worse neurobehavioral functioning following mild moderate and severe tbi a cross sectional multiple cohort study |
| topic | traumatic brain injury tau glial fibrillary acidic protein (GFAP) neurofilament light (NfL) military neurobehavior |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1223960/full |
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