Characterization of Direct Perturbations on Voltage-Gated Sodium Current by Esaxerenone, a Nonsteroidal Mineralocorticoid Receptor Blocker

Characterization of Direct Perturbations on Voltage-Gated Sodium Current by Esaxerenone, a Nonsteroidal Mineralocorticoid Receptor Blocker

Esaxerenone (ESAX; CS-3150, Minnebro<sup>®</sup>) is known to be a newly non-steroidal mineralocorticoid receptor (MR) antagonist. However, its modulatory actions on different types of ionic currents in electrically excitable cells remain largely unanswered. The present investigations we...

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Bibliographic Details
Main Authors:	Wei-Ting Chang, Sheng-Nan Wu
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Biomedicines
Subjects:	esaxerenone voltage-gated Na<sup>+</sup> current persistent Na<sup>+</sup> current current kinetics hysteresis pituitary cell
Online Access:	https://www.mdpi.com/2227-9059/9/5/549

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