The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain
Cells contain numerous membrane-less (MLOs) and multiple membrane-bound organelles. Most of the MLOs have a spherical shape except for a few organelles (that have a filamentous appearance, e.g. FXR1 condensates, L-bodies, and TIS granules). Some MLOs form associations with the membrane-bound organel...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Supramolecular Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667240523000302 |
| _version_ | 1797383632562683904 |
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| author | Kashif Rahim Muhammad Umair Ihtisham Ul Haq |
| author_facet | Kashif Rahim Muhammad Umair Ihtisham Ul Haq |
| author_sort | Kashif Rahim |
| collection | DOAJ |
| description | Cells contain numerous membrane-less (MLOs) and multiple membrane-bound organelles. Most of the MLOs have a spherical shape except for a few organelles (that have a filamentous appearance, e.g. FXR1 condensates, L-bodies, and TIS granules). Some MLOs form associations with the membrane-bound organelles, such as the endoplasmic reticulum (ER). This fact was recently revealed by the discovery of a new, unique filamentous membrane-less organelle called ''TIS granule'' that was directly interlinked and twisted with the endoplasmic reticulum (ER). The most interesting insight of the TIS granules is that the transcribed genetic information carried by 3′ UTR of mRNA is translated by them, which makes them one of the most crucial sub-cellular organelles. Multiple TIS granules form a reticular meshwork with the endoplasmic reticulum (ER), ultimately creating an inter-organelle space or subcellular compartment known as the ''TIGER Domain'' that is enriched with membrane proteins-encoding mRNAs, some intermediate proteins (e.g. HuR) and a few chaperones. TIGER domain enables 3′ UTR-mediated protein–protein interactions (PPIs) between specific & functionally relevant proteins, such as membrane and 3′ UTR dependent proteins. For more than six decades, only ribosomes were credited as solo membrane-less organelles involved in the cell's translation process. However, this review acknowledges and highlights another less familiar translation companion of the ribosome (i.e. TIS granule) and elaborates on its composition, assembly, morphology and complete functionality in an easily understandable way. |
| first_indexed | 2024-03-08T21:23:52Z |
| format | Article |
| id | doaj.art-07df11d943134359986516f8e882a458 |
| institution | Directory Open Access Journal |
| issn | 2667-2405 |
| language | English |
| last_indexed | 2024-03-08T21:23:52Z |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Supramolecular Materials |
| spelling | doaj.art-07df11d943134359986516f8e882a4582023-12-21T07:38:18ZengKeAi Communications Co., Ltd.Supramolecular Materials2667-24052024-12-013100060The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER DomainKashif Rahim0Muhammad Umair1Ihtisham Ul Haq2College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China; Corresponding author at: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.Department of Zoology, Faculty of Biosciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, PakistanJoint Doctoral School, Silesian University of Technology, Akademicka 2A, 44-100, Gliwice, PolandCells contain numerous membrane-less (MLOs) and multiple membrane-bound organelles. Most of the MLOs have a spherical shape except for a few organelles (that have a filamentous appearance, e.g. FXR1 condensates, L-bodies, and TIS granules). Some MLOs form associations with the membrane-bound organelles, such as the endoplasmic reticulum (ER). This fact was recently revealed by the discovery of a new, unique filamentous membrane-less organelle called ''TIS granule'' that was directly interlinked and twisted with the endoplasmic reticulum (ER). The most interesting insight of the TIS granules is that the transcribed genetic information carried by 3′ UTR of mRNA is translated by them, which makes them one of the most crucial sub-cellular organelles. Multiple TIS granules form a reticular meshwork with the endoplasmic reticulum (ER), ultimately creating an inter-organelle space or subcellular compartment known as the ''TIGER Domain'' that is enriched with membrane proteins-encoding mRNAs, some intermediate proteins (e.g. HuR) and a few chaperones. TIGER domain enables 3′ UTR-mediated protein–protein interactions (PPIs) between specific & functionally relevant proteins, such as membrane and 3′ UTR dependent proteins. For more than six decades, only ribosomes were credited as solo membrane-less organelles involved in the cell's translation process. However, this review acknowledges and highlights another less familiar translation companion of the ribosome (i.e. TIS granule) and elaborates on its composition, assembly, morphology and complete functionality in an easily understandable way.http://www.sciencedirect.com/science/article/pii/S2667240523000302Tiger domainTis11bMembraneless organellesER-associated organellesTIS granuleBiomolecular condensates |
| spellingShingle | Kashif Rahim Muhammad Umair Ihtisham Ul Haq The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain Supramolecular Materials Tiger domain Tis11b Membraneless organelles ER-associated organelles TIS granule Biomolecular condensates |
| title | The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain |
| title_full | The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain |
| title_fullStr | The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain |
| title_full_unstemmed | The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain |
| title_short | The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain |
| title_sort | role of filamentous membraneless organelle in 3utr mediated protein protein interfaces and localization tiger domain |
| topic | Tiger domain Tis11b Membraneless organelles ER-associated organelles TIS granule Biomolecular condensates |
| url | http://www.sciencedirect.com/science/article/pii/S2667240523000302 |
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