Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease
Alzheimer’s disease is the most common cause of dementia in the world. Lack of an established pathology makes it difficult to develop suitable approaches and treatment for the disease. Besides known hallmarks, including amyloid β peptides cumulating in plaques and hyperphosphorylated tau forming NFT...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10751 |
| _version_ | 1797591529329524736 |
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| author | Julia Doroszkiewicz Jan Mroczko Piotr Rutkowski Barbara Mroczko |
| author_facet | Julia Doroszkiewicz Jan Mroczko Piotr Rutkowski Barbara Mroczko |
| author_sort | Julia Doroszkiewicz |
| collection | DOAJ |
| description | Alzheimer’s disease is the most common cause of dementia in the world. Lack of an established pathology makes it difficult to develop suitable approaches and treatment for the disease. Besides known hallmarks, including amyloid β peptides cumulating in plaques and hyperphosphorylated tau forming NFTs, inflammation also plays an important role, with known connections to the diet. In AD, adhering to reasonable nutrition according to age-related principles is recommended. The diet should be high in neuroprotective foods, such as polyunsaturated fatty acids, antioxidants, and B vitamins. In addition, foods capable of rising BDNF should be considered because of the known profitable results of this molecule in AD. Adhering to beneficial diets might result in improvements in memory, cognition, and biomarkers and might even reduce the risk of developing AD. In this review, we discuss the effects of various diets, foods, and nutrients on brain health and possible connections to Alzheimer’s disease. |
| first_indexed | 2024-03-11T01:38:43Z |
| format | Article |
| id | doaj.art-07df9dd63d1b4048b12ab21d3ffdddfc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:38:43Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-07df9dd63d1b4048b12ab21d3ffdddfc2023-11-18T16:42:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131075110.3390/ijms241310751Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s DiseaseJulia Doroszkiewicz0Jan Mroczko1Piotr Rutkowski2Barbara Mroczko3Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-089 Bialystok, PolandStaszica Mental Health Center, 15-071 Bialystok, PolandDepartment of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-089 Bialystok, PolandAlzheimer’s disease is the most common cause of dementia in the world. Lack of an established pathology makes it difficult to develop suitable approaches and treatment for the disease. Besides known hallmarks, including amyloid β peptides cumulating in plaques and hyperphosphorylated tau forming NFTs, inflammation also plays an important role, with known connections to the diet. In AD, adhering to reasonable nutrition according to age-related principles is recommended. The diet should be high in neuroprotective foods, such as polyunsaturated fatty acids, antioxidants, and B vitamins. In addition, foods capable of rising BDNF should be considered because of the known profitable results of this molecule in AD. Adhering to beneficial diets might result in improvements in memory, cognition, and biomarkers and might even reduce the risk of developing AD. In this review, we discuss the effects of various diets, foods, and nutrients on brain health and possible connections to Alzheimer’s disease.https://www.mdpi.com/1422-0067/24/13/10751Alzheimer’s diseasedietnutritionBDNFmild cognitive impairment |
| spellingShingle | Julia Doroszkiewicz Jan Mroczko Piotr Rutkowski Barbara Mroczko Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease International Journal of Molecular Sciences Alzheimer’s disease diet nutrition BDNF mild cognitive impairment |
| title | Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease |
| title_full | Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease |
| title_fullStr | Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease |
| title_full_unstemmed | Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease |
| title_short | Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer’s Disease |
| title_sort | molecular aspects of a diet as a new pathway in the prevention and treatment of alzheimer s disease |
| topic | Alzheimer’s disease diet nutrition BDNF mild cognitive impairment |
| url | https://www.mdpi.com/1422-0067/24/13/10751 |
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