Novel effects of hormonal contraceptive use on the plasma proteome.
Hormonal contraceptive (HC) use may increase cardiometabolic risk; however, the effect of HC on emerging cardiometabolic and other disease risk factors is not clear.To determine the association between HC use and plasma proteins involved in established and emerging disease risk pathways.Concentratio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3440362?pdf=render |
| _version_ | 1819265360207020032 |
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| author | Andrea R Josse Bibiana Garcia-Bailo Karina Fischer Ahmed El-Sohemy |
| author_facet | Andrea R Josse Bibiana Garcia-Bailo Karina Fischer Ahmed El-Sohemy |
| author_sort | Andrea R Josse |
| collection | DOAJ |
| description | Hormonal contraceptive (HC) use may increase cardiometabolic risk; however, the effect of HC on emerging cardiometabolic and other disease risk factors is not clear.To determine the association between HC use and plasma proteins involved in established and emerging disease risk pathways.Concentrations of 54 high-abundance plasma proteins were measured simultaneously by LC-MRM/MS in 783 women from the Toronto Nutrigenomics and Health Study. C-reactive protein (CRP) was measured separately. ANCOVA was used to test differences in protein concentrations between users and non-users, and among HC users depending on total hormone dose. Linear regression was used to test the association between duration (years) of HC use and plasma protein concentrations. Principal components analysis (PCA) was used to identify plasma proteomic profiles in users and non-users.After Bonferroni correction, 19 proteins involved in inflammation, innate immunity, coagulation and blood pressure regulation were significantly different between users and non-users (P<0.0009). These differences were replicated across three distinct ethnocultural groups. Traditional markers of glucose and lipid metabolism were also significantly higher among HC users. Neither hormone dose nor duration of use affected protein concentrations. PCA identified 4 distinct proteomic profiles in users and 3 in non-users.HC use was associated with different concentrations of plasma proteins along various disease-related pathways, and these differences were present across different ethnicities. Aside from the known effect of HC on traditional biomarkers of cardiometabolic risk, HC use also affects numerous proteins that may be biomarkers of dysregulation in inflammation, coagulation and blood pressure. |
| first_indexed | 2024-12-23T20:44:08Z |
| format | Article |
| id | doaj.art-07e10c78a0694191befecc60709955aa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T20:44:08Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-07e10c78a0694191befecc60709955aa2022-12-21T17:31:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4516210.1371/journal.pone.0045162Novel effects of hormonal contraceptive use on the plasma proteome.Andrea R JosseBibiana Garcia-BailoKarina FischerAhmed El-SohemyHormonal contraceptive (HC) use may increase cardiometabolic risk; however, the effect of HC on emerging cardiometabolic and other disease risk factors is not clear.To determine the association between HC use and plasma proteins involved in established and emerging disease risk pathways.Concentrations of 54 high-abundance plasma proteins were measured simultaneously by LC-MRM/MS in 783 women from the Toronto Nutrigenomics and Health Study. C-reactive protein (CRP) was measured separately. ANCOVA was used to test differences in protein concentrations between users and non-users, and among HC users depending on total hormone dose. Linear regression was used to test the association between duration (years) of HC use and plasma protein concentrations. Principal components analysis (PCA) was used to identify plasma proteomic profiles in users and non-users.After Bonferroni correction, 19 proteins involved in inflammation, innate immunity, coagulation and blood pressure regulation were significantly different between users and non-users (P<0.0009). These differences were replicated across three distinct ethnocultural groups. Traditional markers of glucose and lipid metabolism were also significantly higher among HC users. Neither hormone dose nor duration of use affected protein concentrations. PCA identified 4 distinct proteomic profiles in users and 3 in non-users.HC use was associated with different concentrations of plasma proteins along various disease-related pathways, and these differences were present across different ethnicities. Aside from the known effect of HC on traditional biomarkers of cardiometabolic risk, HC use also affects numerous proteins that may be biomarkers of dysregulation in inflammation, coagulation and blood pressure.http://europepmc.org/articles/PMC3440362?pdf=render |
| spellingShingle | Andrea R Josse Bibiana Garcia-Bailo Karina Fischer Ahmed El-Sohemy Novel effects of hormonal contraceptive use on the plasma proteome. PLoS ONE |
| title | Novel effects of hormonal contraceptive use on the plasma proteome. |
| title_full | Novel effects of hormonal contraceptive use on the plasma proteome. |
| title_fullStr | Novel effects of hormonal contraceptive use on the plasma proteome. |
| title_full_unstemmed | Novel effects of hormonal contraceptive use on the plasma proteome. |
| title_short | Novel effects of hormonal contraceptive use on the plasma proteome. |
| title_sort | novel effects of hormonal contraceptive use on the plasma proteome |
| url | http://europepmc.org/articles/PMC3440362?pdf=render |
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