Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol
Abstract Background Bruch membrane opening–minimum rim width (BMO–MRW) assessment offers a new diagnostic use in glaucoma patients of the Glaucoma Module Premium Edition (GMPE) available for the Spectralis optical coherence tomography (OCT) system. The objective of our research was to evaluate the d...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-020-1322-8 |
| _version_ | 1831804714276093952 |
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| author | Maria P. Bambo Enrique Fuentemilla Beatriz Cameo Isabel Fuertes Blanca Ferrandez Noemi Güerri Vicente Polo Jose M. Larrosa Luis E. Pablo Elena Garcia-Martin |
| author_facet | Maria P. Bambo Enrique Fuentemilla Beatriz Cameo Isabel Fuertes Blanca Ferrandez Noemi Güerri Vicente Polo Jose M. Larrosa Luis E. Pablo Elena Garcia-Martin |
| author_sort | Maria P. Bambo |
| collection | DOAJ |
| description | Abstract Background Bruch membrane opening–minimum rim width (BMO–MRW) assessment offers a new diagnostic use in glaucoma patients of the Glaucoma Module Premium Edition (GMPE) available for the Spectralis optical coherence tomography (OCT) system. The objective of our research was to evaluate the diagnostic benefits of examining BMO–MRW and peripapillary retinal nerve fibre layer (pRNFL) readings acquired with Spectralis OCT to distinguish between healthy and mild glaucoma patients, comparing those readings with the standard pRNFL application. Moreover, we investigated whether using a particular combination of BMO–MRW and pRNFL parameters with a linear discriminant function (LDF) could further enhance glaucoma diagnosis. Methods One hundred thirty-six eyes from 136 individuals were incorporated into this observational, prospective cross-sectional study: 68 mild primary open-angle glaucoma (POAG) patients according to the Hodapp-Parrish-Anderson criteria (mean deviation between 0 and − 6 dB) and 68 healthy control subjects selected by Propensity Score Matching. MRW and pRNFL thickness around the disc (diameters: 3.5 mm, 4.1 mm, and 4.7 mm) were obtained using the BMO–MRW protocol, and pRNFL thickness at 3.5 mm was obtained with the standard glaucoma application. The group data were contrasted. One sample was chosen at random to develop the LDF (teaching set: 34 healthy subjects and 34 POAG patients) using a combination of MRW and pRNFL parameters (acquired with the BMO–MRW protocol); the other sample provided a test of how the LDF performed on an independent group (validating set: 34 healthy subjects and 34 POAG patients). The receiver operating curves (ROCs) were plotted for every measurement and contrasted with the proposed LDF. The OCT parameters with the best area under the receiver operating characteristic curve (AUC) were determined. Results Global MRW and pRNFL thicknesses were significantly thinner in the POAG group (p < 0.001). The BMO–MRW parameters showed good diagnostic accuracy; the largest AUCs reached 0.875 for the LDF and 0.879 for global RNFL thickness using the standard glaucoma application. There were no statistical differences between the AUCs calculated. Conclusions BMO–MRW parameters show a strong capability to differentiate between mild glaucoma and control eyes. Our LDF based on the new BMO–MRW OCT protocol did not perform better than isolated parameters. |
| first_indexed | 2024-12-22T19:12:22Z |
| format | Article |
| id | doaj.art-07e1ad39972b450b979b314e4c69cfaf |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-22T19:12:22Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-07e1ad39972b450b979b314e4c69cfaf2022-12-21T18:15:38ZengBMCBMC Ophthalmology1471-24152020-01-012011810.1186/s12886-020-1322-8Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocolMaria P. Bambo0Enrique Fuentemilla1Beatriz Cameo2Isabel Fuertes3Blanca Ferrandez4Noemi Güerri5Vicente Polo6Jose M. Larrosa7Luis E. Pablo8Elena Garcia-Martin9Ophthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalOphthalmology Department, Miguel Servet University HospitalAbstract Background Bruch membrane opening–minimum rim width (BMO–MRW) assessment offers a new diagnostic use in glaucoma patients of the Glaucoma Module Premium Edition (GMPE) available for the Spectralis optical coherence tomography (OCT) system. The objective of our research was to evaluate the diagnostic benefits of examining BMO–MRW and peripapillary retinal nerve fibre layer (pRNFL) readings acquired with Spectralis OCT to distinguish between healthy and mild glaucoma patients, comparing those readings with the standard pRNFL application. Moreover, we investigated whether using a particular combination of BMO–MRW and pRNFL parameters with a linear discriminant function (LDF) could further enhance glaucoma diagnosis. Methods One hundred thirty-six eyes from 136 individuals were incorporated into this observational, prospective cross-sectional study: 68 mild primary open-angle glaucoma (POAG) patients according to the Hodapp-Parrish-Anderson criteria (mean deviation between 0 and − 6 dB) and 68 healthy control subjects selected by Propensity Score Matching. MRW and pRNFL thickness around the disc (diameters: 3.5 mm, 4.1 mm, and 4.7 mm) were obtained using the BMO–MRW protocol, and pRNFL thickness at 3.5 mm was obtained with the standard glaucoma application. The group data were contrasted. One sample was chosen at random to develop the LDF (teaching set: 34 healthy subjects and 34 POAG patients) using a combination of MRW and pRNFL parameters (acquired with the BMO–MRW protocol); the other sample provided a test of how the LDF performed on an independent group (validating set: 34 healthy subjects and 34 POAG patients). The receiver operating curves (ROCs) were plotted for every measurement and contrasted with the proposed LDF. The OCT parameters with the best area under the receiver operating characteristic curve (AUC) were determined. Results Global MRW and pRNFL thicknesses were significantly thinner in the POAG group (p < 0.001). The BMO–MRW parameters showed good diagnostic accuracy; the largest AUCs reached 0.875 for the LDF and 0.879 for global RNFL thickness using the standard glaucoma application. There were no statistical differences between the AUCs calculated. Conclusions BMO–MRW parameters show a strong capability to differentiate between mild glaucoma and control eyes. Our LDF based on the new BMO–MRW OCT protocol did not perform better than isolated parameters.https://doi.org/10.1186/s12886-020-1322-8Linear discriminant functionOptical coherence tomographyGlaucoma |
| spellingShingle | Maria P. Bambo Enrique Fuentemilla Beatriz Cameo Isabel Fuertes Blanca Ferrandez Noemi Güerri Vicente Polo Jose M. Larrosa Luis E. Pablo Elena Garcia-Martin Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol BMC Ophthalmology Linear discriminant function Optical coherence tomography Glaucoma |
| title | Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol |
| title_full | Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol |
| title_fullStr | Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol |
| title_full_unstemmed | Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol |
| title_short | Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol |
| title_sort | diagnostic capability of a linear discriminant function applied to a novel spectralis oct glaucoma detection protocol |
| topic | Linear discriminant function Optical coherence tomography Glaucoma |
| url | https://doi.org/10.1186/s12886-020-1322-8 |
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