Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents
Isoflavones have been identified as potential anti-diabetic agents, but adverse side effects especially at high dosage has continued to plague their clinical uptake. We explore the benefits of individual and co-treatment of diabetic rodents with isoflavone-rich kudzu extract and chaga extract based...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624000628 |
| _version_ | 1797277330176999424 |
|---|---|
| author | Kingsley C. Duru Elena G. Kovaleva Cara M. Hildreth Alberto P. Avolio Jacqueline K. Phillips Mark Butlin |
| author_facet | Kingsley C. Duru Elena G. Kovaleva Cara M. Hildreth Alberto P. Avolio Jacqueline K. Phillips Mark Butlin |
| author_sort | Kingsley C. Duru |
| collection | DOAJ |
| description | Isoflavones have been identified as potential anti-diabetic agents, but adverse side effects especially at high dosage has continued to plague their clinical uptake. We explore the benefits of individual and co-treatment of diabetic rodents with isoflavone-rich kudzu extract and chaga extract based on effect on glycemic control, regeneration of pancreatic β-cells (immunofluorescence staining assessment of pancreatic insulin and pancreatic and duodenal homeobox 1 (PDX-1) expression), cardiac function (including measurements of left ventricular hemodynamics, and arterial stiffness) and kidney function. Treatment of diabetic rodents with either isoflavone or chaga extract improved glycemic control, enhanced the co-expression of insulin and PDX-1, prevented cardiac hypertrophy, and ameliorated hypercellularity of the glomerulus, expansion of the mesangial matrix and deposition of collagen in kidney tissues. The use of both compounds combined did not provide additional benefits beyond that of each used singly. Further research focusing on exploring the optimal dosage of these combined therapies in experimental diabetes models is highly recommended. |
| first_indexed | 2024-03-07T15:47:05Z |
| format | Article |
| id | doaj.art-07e1ba19e9834db78f09aecbd51491e9 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-07T15:47:05Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-07e1ba19e9834db78f09aecbd51491e92024-03-05T04:29:36ZengElsevierJournal of Functional Foods1756-46462024-03-01114106060Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodentsKingsley C. Duru0Elena G. Kovaleva1Cara M. Hildreth2Alberto P. Avolio3Jacqueline K. Phillips4Mark Butlin5Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Center for Advanced Biotechnology and Medicine, Rutgers University, USA; Ural Federal University, RussiaUral Federal University, RussiaMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, AustraliaMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, AustraliaMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Corresponding authors.Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Corresponding authors.Isoflavones have been identified as potential anti-diabetic agents, but adverse side effects especially at high dosage has continued to plague their clinical uptake. We explore the benefits of individual and co-treatment of diabetic rodents with isoflavone-rich kudzu extract and chaga extract based on effect on glycemic control, regeneration of pancreatic β-cells (immunofluorescence staining assessment of pancreatic insulin and pancreatic and duodenal homeobox 1 (PDX-1) expression), cardiac function (including measurements of left ventricular hemodynamics, and arterial stiffness) and kidney function. Treatment of diabetic rodents with either isoflavone or chaga extract improved glycemic control, enhanced the co-expression of insulin and PDX-1, prevented cardiac hypertrophy, and ameliorated hypercellularity of the glomerulus, expansion of the mesangial matrix and deposition of collagen in kidney tissues. The use of both compounds combined did not provide additional benefits beyond that of each used singly. Further research focusing on exploring the optimal dosage of these combined therapies in experimental diabetes models is highly recommended.http://www.sciencedirect.com/science/article/pii/S1756464624000628IsoflavonesDiabetesArterial stiffnessRenal functionInonotus obliquusCardiac function |
| spellingShingle | Kingsley C. Duru Elena G. Kovaleva Cara M. Hildreth Alberto P. Avolio Jacqueline K. Phillips Mark Butlin Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents Journal of Functional Foods Isoflavones Diabetes Arterial stiffness Renal function Inonotus obliquus Cardiac function |
| title | Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents |
| title_full | Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents |
| title_fullStr | Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents |
| title_full_unstemmed | Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents |
| title_short | Synergistic effect of isoflavone-rich kudzu root extract and Inonotus obliquus (chaga) extract on an induced diabetes model in rodents |
| title_sort | synergistic effect of isoflavone rich kudzu root extract and inonotus obliquus chaga extract on an induced diabetes model in rodents |
| topic | Isoflavones Diabetes Arterial stiffness Renal function Inonotus obliquus Cardiac function |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000628 |
| work_keys_str_mv | AT kingsleycduru synergisticeffectofisoflavonerichkudzurootextractandinonotusobliquuschagaextractonaninduceddiabetesmodelinrodents AT elenagkovaleva synergisticeffectofisoflavonerichkudzurootextractandinonotusobliquuschagaextractonaninduceddiabetesmodelinrodents AT caramhildreth synergisticeffectofisoflavonerichkudzurootextractandinonotusobliquuschagaextractonaninduceddiabetesmodelinrodents AT albertopavolio synergisticeffectofisoflavonerichkudzurootextractandinonotusobliquuschagaextractonaninduceddiabetesmodelinrodents AT jacquelinekphillips synergisticeffectofisoflavonerichkudzurootextractandinonotusobliquuschagaextractonaninduceddiabetesmodelinrodents AT markbutlin synergisticeffectofisoflavonerichkudzurootextractandinonotusobliquuschagaextractonaninduceddiabetesmodelinrodents |