The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for Vials
In the process of manufacture and transportation, vials are prone to breakage and cracks. Oxygen (O<sub>2</sub>) in the air entering vials can lead to the deterioration of medicine and a reduction in pesticide effects, threatening the life of patients. Therefore, accurate measurement of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/23/5/2438 |
| _version_ | 1797614344036417536 |
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| author | Xiao Chen Hao Sun Wei Huang Jiayi Jin Mingxu Su Huinan Yang |
| author_facet | Xiao Chen Hao Sun Wei Huang Jiayi Jin Mingxu Su Huinan Yang |
| author_sort | Xiao Chen |
| collection | DOAJ |
| description | In the process of manufacture and transportation, vials are prone to breakage and cracks. Oxygen (O<sub>2</sub>) in the air entering vials can lead to the deterioration of medicine and a reduction in pesticide effects, threatening the life of patients. Therefore, accurate measurement of the headspace O<sub>2</sub> concentration for vials is crucial to ensure pharmaceutical quality. In this invited paper, a novel headspace oxygen concentration measurement (HOCM) sensor for vials was developed based on tunable diode laser absorption spectroscopy (TDLAS). First, a long–optical–path multi–pass cell was designed by optimizing the original system. Moreover, vials with different O<sub>2</sub> concentrations (0%, 5%, 10%, 15%, 20%, and 25%) were measured with this optimized system in order to study the relationship between the leakage coefficient and O<sub>2</sub> concentration; the root mean square error of the fitting was 0.13. Moreover, the measurement accuracy indicates that the novel HOCM sensor achieved an average percentage error of 1.9%. Sealed vials with different leakage holes (4, 6, 8, and 10 mm) were prepared to investigate the variation in the headspace O<sub>2</sub> concentration with time. The results show that the novel HOCM sensor is non-invasive and has a fast response and high accuracy, with prospects in applications for online quality supervision and management of production lines. |
| first_indexed | 2024-03-11T07:11:04Z |
| format | Article |
| id | doaj.art-07e2c7021c3c4ca19e49c0804eacd1af |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-11T07:11:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-07e2c7021c3c4ca19e49c0804eacd1af2023-11-17T08:34:43ZengMDPI AGSensors1424-82202023-02-01235243810.3390/s23052438The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for VialsXiao Chen0Hao Sun1Wei Huang2Jiayi Jin3Mingxu Su4Huinan Yang5School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaIn the process of manufacture and transportation, vials are prone to breakage and cracks. Oxygen (O<sub>2</sub>) in the air entering vials can lead to the deterioration of medicine and a reduction in pesticide effects, threatening the life of patients. Therefore, accurate measurement of the headspace O<sub>2</sub> concentration for vials is crucial to ensure pharmaceutical quality. In this invited paper, a novel headspace oxygen concentration measurement (HOCM) sensor for vials was developed based on tunable diode laser absorption spectroscopy (TDLAS). First, a long–optical–path multi–pass cell was designed by optimizing the original system. Moreover, vials with different O<sub>2</sub> concentrations (0%, 5%, 10%, 15%, 20%, and 25%) were measured with this optimized system in order to study the relationship between the leakage coefficient and O<sub>2</sub> concentration; the root mean square error of the fitting was 0.13. Moreover, the measurement accuracy indicates that the novel HOCM sensor achieved an average percentage error of 1.9%. Sealed vials with different leakage holes (4, 6, 8, and 10 mm) were prepared to investigate the variation in the headspace O<sub>2</sub> concentration with time. The results show that the novel HOCM sensor is non-invasive and has a fast response and high accuracy, with prospects in applications for online quality supervision and management of production lines.https://www.mdpi.com/1424-8220/23/5/2438measurementO<sub>2</sub>vialconcentrationsensor |
| spellingShingle | Xiao Chen Hao Sun Wei Huang Jiayi Jin Mingxu Su Huinan Yang The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for Vials Sensors measurement O<sub>2</sub> vial concentration sensor |
| title | The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for Vials |
| title_full | The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for Vials |
| title_fullStr | The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for Vials |
| title_full_unstemmed | The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for Vials |
| title_short | The Development of a Novel Headspace O<sub>2</sub> Concentration Measurement Sensor for Vials |
| title_sort | development of a novel headspace o sub 2 sub concentration measurement sensor for vials |
| topic | measurement O<sub>2</sub> vial concentration sensor |
| url | https://www.mdpi.com/1424-8220/23/5/2438 |
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