Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer

Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer

Abstract Background Oxaliplatin resistance usually leads to therapeutic failure and poor prognosis in colorectal cancer (CRC), while the underlying mechanisms are not yet fully understood. Metabolic reprogramming is strongly linked to drug resistance, however, the role and mechanism of metabolic rep...

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Bibliographic Details
Main Authors: Yuting Huang, Szehoi Chan, Shuna Chen, Xueqi Liu, Miao Li, Liyuan Zheng, Zhaoxia Dong, Ziyi Yang, Zixuan Liu, Disheng Zhou, Xingding Zhang, Bo Zhang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Oxaliplatin resistance
Purine metabolism
IMPDH2
β‑catenin
Apoptosis
Online Access:https://doi.org/10.1186/s12967-024-04934-0

Internet

https://doi.org/10.1186/s12967-024-04934-0

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