Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase to produce sufficient PtdIns-4-phosphate (PtdIn...

Full description

Bibliographic Details
Main Authors:	Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-39978-1

Similar Items

Regulation of phosphoinositide metabolism in Apicomplexan parasites
by: Angela Arabiotorre, et al.
Published: (2023-09-01)

LncRNA PITPNA-AS1 mediates the diagnostic potential of miR-129-5p in prostate cancer
by: Zhaolu Song, et al.
Published: (2024-07-01)

Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults
by: Darel Wee Kiat Toh, et al.
Published: (2024-02-01)

PITPNA-AS1 Inhibits Cell Proliferation and Migration in Ovarian Cancer by Regulating the MIR-223-3p/RHOB Axis
by: Fei Zhang, et al.
Published: (2024-04-01)

LncRNA PITPNA‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA
by: Ping Ren, et al.
Published: (2020-10-01)

Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis
by: Rashid, Rafi, et al.
Published: (2017)

Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis.
by: Rafi Rashid, et al.
Published: (2017-01-01)

Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism
by: Zhigang Xie, et al.
Published: (2016-02-01)

FasR Regulates Fatty Acid Biosynthesis and Is Essential for Virulence of Mycobacterium tuberculosis
by: Sonia Mondino, et al.
Published: (2020-10-01)

A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation
by: Xiao-Ru Chen, et al.
Published: (2024-04-01)

Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate
by: Jacinda Chen, et al.
Published: (2023-02-01)

Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation.
by: Shijun Wang, et al.
Published: (2012-01-01)

Transient complexity of E. Coli lipidome is explained by fatty acyl synthesis and cyclopropanation
by: Berezhnoy, Nikolay V., et al.
Published: (2023)

Transient Complexity of <i>E. coli</i> Lipidome Is Explained by Fatty Acyl Synthesis and Cyclopropanation
by: Nikolay V. Berezhnoy, et al.
Published: (2022-08-01)

Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women
by: Hannah E. J. Yong, et al.
Published: (2023-05-01)

The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research
by: Sarah Greve, et al.
Published: (2022-08-01)

Bacterial lipopolysaccharide core structures mediate effects of butanol ingress
by: Guo, Jingjing, et al.
Published: (2021)

Transgenic overexpression of microRNA-30d in pancreatic beta-cells progressively regulates beta-cell function and identity
by: Yiping Mao, et al.
Published: (2022-07-01)

Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis
by: Rashid, Rafi, et al.
Published: (2023)

Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis
by: Rafi Rashid, et al.
Published: (2023-02-01)

Regulation of Insulin Clearance by Non-Esterified Fatty Acids
by: Sonia M. Najjar, et al.
Published: (2022-08-01)

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta
by: Emelyne Teo, et al.
Published: (2019-10-01)

Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental 13C-DHA-metabolism, altering their relationships with birthweight
by: Oliver C. Watkins, et al.
Published: (2022-09-01)

Paradigm shift required for translational research on the brain
by: Jong Hyuk Yoon, et al.
Published: (2024-05-01)

Intrarenal Dopaminergic System Is Dysregulated in SS-<i>Resp18<sup>mutant</sup></i> Rats
by: Usman M. Ashraf, et al.
Published: (2023-01-01)

Editorial: Molecular determinants of protein assemblies in health and disease, Volume II
by: Verena Kohler, et al.
Published: (2023-12-01)

Editorial: Molecular determinants of protein assemblies in health and disease
by: Sonja Kroschwald, et al.
Published: (2022-12-01)

Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II
by: Chwee Tat Koe, et al.
Published: (2018-02-01)

Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes
by: Chandan Sona, et al.
Published: (2022-03-01)

Cholesterol Redistribution in Pancreatic β-Cells: A Flexible Path to Regulate Insulin Secretion
by: Alessandra Galli, et al.
Published: (2023-01-01)

Central limit theorem in the symmetric group
by: Vytas Zacharovas
Published: (1999-12-01)

Apie valdovo vienatvę (Rec. kn.: RIER, Ianina. Pravitel' i obshchestvo na belorusskikh zemliakh v XIII – pervoi treti XV v.: osnavnye mekhanizmy politogeneza, legitimizatsii i sakralizatsii vlasti. Mogilev, 2020. – 256 s. ISBN 978-985-568-658-4)
by: Vytas Jankauskas
Published: (2023-12-01)

Ką mums gali pasakyti Mindaugo dovanojimas vyskupui Kristijonui? Apmąstymai galimos polemikos fone | The Donation of King Mindaugas to the Lithuanian Bishop Christian: Considerations on a Possible Controversy
by: Vytas Jankauskas
Published: (2023-12-01)

The Economics of ALN: Some Issues
by: Lanny Arvan
Published: (2019-03-01)

Varieties of Artificial Moral Agency and the New Control Problem
by: Marcus Arvan
Published: (2022-12-01)

Proinsulin misfolding is an early event in the progression to type 2 diabetes
by: Anoop Arunagiri, et al.
Published: (2019-06-01)

Las finanzas éticas como instrumento al servicio de la economía solidaria. La experiencia de Coop57
by: Raimon Gassiot Ballbè
Published: (2013-03-01)

IJCM_214A: Digital interventions for childhood malnutrition in a tribal area of Andhra Pradesh: Understanding the problem through a health system perspective
by: Roy Adrija
Published: (2024-04-01)

Intermittent Fasting and Diets: A Fad or Fact
by: Adrija Mehta
Published: (2023-07-01)

Art as Resistance in Shaheen Bagh
by: Adrija Ghosh
Published: (2020-07-01)