Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury

Silibinin Effect on Fas/FasL, HMGB1, and CD45 Expressions in a Rat Model Subjected to Liver Ischemia-Reperfusion Injury

Purpose: We investigated the hepatoprotective effect of Silibinin (SLB) to ischemia-reperfusion (I/R) rat model, by evaluating the histological expression of the tissue markers Fas/FasL, HMGB-1 and CD45, and SLB pharmacokinetics. Methods: Seventy-three Wistar-type male rats were randomized in 11 gro...

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Bibliographic Details
Main Authors: Alexandra K. Tsaroucha, Georgia Valsami, Nikolaos Kostomitsopoulos, Maria Lambropoulou, Constantinos Anagnostopoulos, Eirini Christodoulou, Evangelos Falidas, Afrodite Betsou, Michael Pitiakoudis, Constantinos E. Simopoulos
Format: Article
Language:English
Published: Taylor & Francis Group 2018-11-01
Series:Journal of Investigative Surgery
Subjects:
liver ischemia-reperfusion injury
silibinin
fas/fasl
hmgb-1
cd45
pharmacokinetics
Online Access:http://dx.doi.org/10.1080/08941939.2017.1360416

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