Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks
The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling even...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27280-x |
| _version_ | 1818401445239586816 |
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| author | Maik Müller Fabienne Gräbnitz Niculò Barandun Yang Shen Fabian Wendt Sebastian N. Steiner Yannik Severin Stefan U. Vetterli Milon Mondal James R. Prudent Raphael Hofmann Marc van Oostrum Roman C. Sarott Alexey I. Nesvizhskii Erick M. Carreira Jeffrey W. Bode Berend Snijder John A. Robinson Martin J. Loessner Annette Oxenius Bernd Wollscheid |
| author_facet | Maik Müller Fabienne Gräbnitz Niculò Barandun Yang Shen Fabian Wendt Sebastian N. Steiner Yannik Severin Stefan U. Vetterli Milon Mondal James R. Prudent Raphael Hofmann Marc van Oostrum Roman C. Sarott Alexey I. Nesvizhskii Erick M. Carreira Jeffrey W. Bode Berend Snijder John A. Robinson Martin J. Loessner Annette Oxenius Bernd Wollscheid |
| author_sort | Maik Müller |
| collection | DOAJ |
| description | The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events. |
| first_indexed | 2024-12-14T07:52:35Z |
| format | Article |
| id | doaj.art-07e4f618935147f798b726c0fe3eb3c4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:52:35Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-07e4f618935147f798b726c0fe3eb3c42022-12-21T23:10:39ZengNature PortfolioNature Communications2041-17232021-12-0112111710.1038/s41467-021-27280-xLight-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networksMaik Müller0Fabienne Gräbnitz1Niculò Barandun2Yang Shen3Fabian Wendt4Sebastian N. Steiner5Yannik Severin6Stefan U. Vetterli7Milon Mondal8James R. Prudent9Raphael Hofmann10Marc van Oostrum11Roman C. Sarott12Alexey I. Nesvizhskii13Erick M. Carreira14Jeffrey W. Bode15Berend Snijder16John A. Robinson17Martin J. Loessner18Annette Oxenius19Bernd Wollscheid20Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)Department of Biology, ETH Zurich, Institute of MicrobiologyDepartment of Biology, ETH Zurich, Institute of MicrobiologyInstitute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH ZurichDepartment of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)Department of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)Institute of Molecular Systems Biology, Department of Biology, ETH ZurichChemistry Department, University of ZurichChemistry Department, University of ZurichCentrose LLCLaboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH ZurichDepartment of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH ZurichDepartment of Pathology, University of MichiganLaboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH ZurichLaboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH ZurichSwiss Institute of Bioinformatics (SIB)Chemistry Department, University of ZurichInstitute of Food Nutrition and Health, Department of Health Sciences and Technology, ETH ZurichDepartment of Biology, ETH Zurich, Institute of MicrobiologyDepartment of Health Sciences and Technology (D-HEST), ETH Zurich, Institute of Translational Medicine (ITM)The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events.https://doi.org/10.1038/s41467-021-27280-x |
| spellingShingle | Maik Müller Fabienne Gräbnitz Niculò Barandun Yang Shen Fabian Wendt Sebastian N. Steiner Yannik Severin Stefan U. Vetterli Milon Mondal James R. Prudent Raphael Hofmann Marc van Oostrum Roman C. Sarott Alexey I. Nesvizhskii Erick M. Carreira Jeffrey W. Bode Berend Snijder John A. Robinson Martin J. Loessner Annette Oxenius Bernd Wollscheid Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks Nature Communications |
| title | Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks |
| title_full | Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks |
| title_fullStr | Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks |
| title_full_unstemmed | Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks |
| title_short | Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks |
| title_sort | light mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks |
| url | https://doi.org/10.1038/s41467-021-27280-x |
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