The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility

The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility

Varicocele (VC) is the most common abnormality identified in men evaluated for hypofertility. Increased levels of reactive oxygen species (ROS) and reduced antioxidants concentrations are key contributors in varicocele-mediated hypofertility. Moreover, inflammation and alterations in testicular immu...

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Bibliographic Details
Main Authors: Giulia Poli, Consuelo Fabi, Chiara Sugoni, Marina Maria Bellet, Claudio Costantini, Giovanni Luca, Stefano Brancorsini
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
NLRP3 inflammasome
varicocele
male hypofertility
reactive oxygen species
antioxidants
Online Access:https://www.mdpi.com/1422-0067/23/9/5233

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