Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review
Background: The symbiotic relationship between the gut microbiota and cardiovascular health has become a main point in contemporary research, offering valuable insights into the pathogenesis of cardiovascular diseases (CVDs). This review aims to comprehensively examine the bidirectional communicati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2024-02-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/48312 |
| _version_ | 1797299334610419712 |
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| author | Julia Zarębska Julia Krasnoborska Sylwia Samojedny Maciej Superson Katarzyna Szmyt Katarzyna Szymańska Kamil Walczak Klaudia Wilk-Trytko Łukasz Zarębski |
| author_facet | Julia Zarębska Julia Krasnoborska Sylwia Samojedny Maciej Superson Katarzyna Szmyt Katarzyna Szymańska Kamil Walczak Klaudia Wilk-Trytko Łukasz Zarębski |
| author_sort | Julia Zarębska |
| collection | DOAJ |
| description |
Background: The symbiotic relationship between the gut microbiota and cardiovascular health has become a main point in contemporary research, offering valuable insights into the pathogenesis of cardiovascular diseases (CVDs). This review aims to comprehensively examine the bidirectional communication between gut microbial communities and the cardiovascular system, explaining the intricate mechanisms that connect gut dysbiosis to the initiation and progression of CVDs.
Material and Methods: A systematic literature review was conducted to compile and analyze relevant studies investigating the impact of the gut microbiota on cardiovascular health. Emphasis was placed on explaining the molecular and physiological mechanisms underlying the interaction between gut microbes and cardiovascular function.
Results: Our review confirmed evidence linking gut microbiota-derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide and lipopolysaccharides to vascular function and inflammation. Additionally, we explored the modulation of host metabolism and immune responses by gut microbes, providing insights into their roles in atherosclerosis and hypertension. The review highlight the influence of diet and lifestyle on shaping the gut microbiome and, consequently, cardiovascular outcomes.
Conclusions: Gut microbiota plays a crucial role in cardiovascular health and is involved in the start and development of various heart diseases. The identified molecular and physiological mechanisms highlight the need for complete understanding of the gut-cardiovascular axis. Moreover, the review emphasizes the potential of microbiota-targeted interventions, including probiotics and fecal microbiota transplantation, as innovative strategies for preventing and managing CVDs.
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| first_indexed | 2024-03-07T22:48:10Z |
| format | Article |
| id | doaj.art-07e608874ed24d6d88e3844265435245 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-03-07T22:48:10Z |
| publishDate | 2024-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-07e608874ed24d6d88e38442654352452024-02-23T11:52:52ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062024-02-016210.12775/JEHS.2024.62.009Gut Microbiota and Its Implications for Cardiovascular Diseases – a ReviewJulia Zarębska0Julia Krasnoborska1Sylwia Samojedny2Maciej Superson3Katarzyna Szmyt4Katarzyna Szymańska5Kamil Walczak6Klaudia Wilk-Trytko7Łukasz Zarębski8Medical University of LublinMedicadent Clinic, Piątkowska 110A, 60-649 Poznań, PolandUniversity Clinical Hospital Fryderyk Chopin, Szopena 2, 35-055 Rzeszów, PolandUniversity Clinical Hospital Fryderyk Chopin, Szopena 2, 35-055 Rzeszów, PolandUniversity Clinical Hospital Fryderyk Chopin, Szopena 2, 35-055 Rzeszów, PolandUniversity Clinical Hospital Fryderyk Chopin, Szopena 2, 35-055 Rzeszów, PolandUniversity Clinical Hospital Fryderyk Chopin, Szopena 2, 35-055 Rzeszów, Poland3University Clinical Hospital Fryderyk Chopin, Szopena 2, 35-055 Rzeszów, PolandUniversity Clinical Hospital Fryderyk Chopin, Szopena 2, 35-055 Rzeszów, Poland Background: The symbiotic relationship between the gut microbiota and cardiovascular health has become a main point in contemporary research, offering valuable insights into the pathogenesis of cardiovascular diseases (CVDs). This review aims to comprehensively examine the bidirectional communication between gut microbial communities and the cardiovascular system, explaining the intricate mechanisms that connect gut dysbiosis to the initiation and progression of CVDs. Material and Methods: A systematic literature review was conducted to compile and analyze relevant studies investigating the impact of the gut microbiota on cardiovascular health. Emphasis was placed on explaining the molecular and physiological mechanisms underlying the interaction between gut microbes and cardiovascular function. Results: Our review confirmed evidence linking gut microbiota-derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide and lipopolysaccharides to vascular function and inflammation. Additionally, we explored the modulation of host metabolism and immune responses by gut microbes, providing insights into their roles in atherosclerosis and hypertension. The review highlight the influence of diet and lifestyle on shaping the gut microbiome and, consequently, cardiovascular outcomes. Conclusions: Gut microbiota plays a crucial role in cardiovascular health and is involved in the start and development of various heart diseases. The identified molecular and physiological mechanisms highlight the need for complete understanding of the gut-cardiovascular axis. Moreover, the review emphasizes the potential of microbiota-targeted interventions, including probiotics and fecal microbiota transplantation, as innovative strategies for preventing and managing CVDs. https://apcz.umk.pl/JEHS/article/view/48312Gut MicrobiotaCardiovascular DiseasesDysbiosis |
| spellingShingle | Julia Zarębska Julia Krasnoborska Sylwia Samojedny Maciej Superson Katarzyna Szmyt Katarzyna Szymańska Kamil Walczak Klaudia Wilk-Trytko Łukasz Zarębski Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review Journal of Education, Health and Sport Gut Microbiota Cardiovascular Diseases Dysbiosis |
| title | Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review |
| title_full | Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review |
| title_fullStr | Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review |
| title_full_unstemmed | Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review |
| title_short | Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review |
| title_sort | gut microbiota and its implications for cardiovascular diseases a review |
| topic | Gut Microbiota Cardiovascular Diseases Dysbiosis |
| url | https://apcz.umk.pl/JEHS/article/view/48312 |
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